Abstract：
Sulfoxaflor is a widely used fourth-generation neonicotinoid pesticide, which has been detected in biological and environmental samples. Sulfoxaflor can potentially be exposed to humans via the food chain, thus understanding its toxic effects and enantioselective bioaccumulation is crucial. In this study, toxicokinetics, bioaccumulation, tissue distribution and enantiomeric profiles of sulfoxaflor in rats were investigated through single oral exposure and 28-days continuous exposure experiment. Sulfoxaflor mainly accumulated in liver and kidney, and the (-)-2R,3R-sulfoxaflor and (-)-2S,3R-sulfoxaflor had higher enrichment than their enantiomers in rats. The toxicological effects were evaluated after 28-days exposure. Slight inflammation in liver and kidney were observed by histopathology. Sphingolipid, amino acid, and vitamin B6 metabolism pathways were significantly disturbed in metabonomics analysis. These toxicities were in compliance with dose-dependent effects. These results improve understanding of enantioselective bioaccumulation and the potential health risk of sulfoxaflor.
摘要：
Sulfoxaflor是一种广泛使用的第四代新烟碱类农药，已在生物和环境样本中检测到。Sulfoxaflor可能通过食物链暴露于人类，因此，了解其毒性作用和对映选择性生物累积至关重要。在这项研究中,毒物动力学，生物蓄积性,通过单次口服暴露和28天连续暴露实验，研究了磺胺在大鼠体内的组织分布和对映体谱。Sulfoxaflor主要在肝脏和肾脏中积累，和（-）-2R，3R-sufloxaflor和(-)-2S，3R-sufloxaflor在大鼠中的富集度高于其对映体。暴露28天后评估毒理学效果。通过组织病理学观察到肝脏和肾脏的轻度炎症。鞘脂，氨基酸,在代谢组学分析中，维生素B6代谢途径受到显著干扰。这些毒性符合剂量依赖性效应。这些结果提高了对映体选择性生物累积和磺胺的潜在健康风险的认识。
