PDF(Pubmed)
Abstract：
Long-COVID is a multisystem disease that can lead to significant impairments in health-related quality of life (HRQoL). Following COVID-19 infection, abnormalities on pulmonary function tests (PFT) are common. The primary aim of this study is to evaluate for any correlation between PFT abnormalities and impairment in HRQoL scores following COVID-19 infection.
This is an analysis of a prospective cohort of patients in Louisville, KY who were infected with COVID-19. Data collected included demographics, past medical history, laboratory tests, PFTs, and several HRQoL questionnaires such as the EuroQol 5 Dimension HRQoL questionnaire (EQ-5D-5 L), Generalized Anxiety Disorder 7 (GAD-7), Patient Health Questionnaire (PHQ-9), and Posttraumatic stress disorder checklist for DSM-5 (PCL-5). Descriptive statistics were performed, comparing PFTs (normal vs abnormal) and time since COVID-19 infection (3- vs 6- vs ≥ 12 months).
There were no significant differences in FEV1, FVC, or the percentage of patients with abnormal PFTs over time after COVID-19 infection. Following COVID-19, patients with normal PFTs had worse impairment in mobility HRQoL scores and change in GAD-7 scores over time. There were no differences over time in any of the HRQoL scores among patients with abnormal PFTs.
Among patients with an abnormal PFT, there was no temporal association with HRQoL scores as measured by EQ-5D-5 L, GAD-7, PHQ-9, and PCL-5. Among patients with a normal PFT, mobility impairment and anxiety may be associated with COVID-19 infection. Following COVID-19 infection, impairment in HRQoL scores is not completely explained by the presence of abnormalities on spirometry.
This is an analysis of a prospective cohort of patients in Louisville, KY who were infected with COVID-19. Data collected included demographics, past medical history, laboratory tests, PFTs, and several HRQoL questionnaires such as the EuroQol 5 Dimension HRQoL questionnaire (EQ-5D-5 L), Generalized Anxiety Disorder 7 (GAD-7), Patient Health Questionnaire (PHQ-9), and Posttraumatic stress disorder checklist for DSM-5 (PCL-5). Descriptive statistics were performed, comparing PFTs (normal vs abnormal) and time since COVID-19 infection (3- vs 6- vs ≥ 12 months).
There were no significant differences in FEV1, FVC, or the percentage of patients with abnormal PFTs over time after COVID-19 infection. Following COVID-19, patients with normal PFTs had worse impairment in mobility HRQoL scores and change in GAD-7 scores over time. There were no differences over time in any of the HRQoL scores among patients with abnormal PFTs.
Among patients with an abnormal PFT, there was no temporal association with HRQoL scores as measured by EQ-5D-5 L, GAD-7, PHQ-9, and PCL-5. Among patients with a normal PFT, mobility impairment and anxiety may be associated with COVID-19 infection. Following COVID-19 infection, impairment in HRQoL scores is not completely explained by the presence of abnormalities on spirometry.
摘要：
背景：长型COVID是一种多系统疾病，可导致与健康相关的生活质量（HRQoL）严重受损。COVID-19感染后，肺功能检查（PFT）异常很常见。这项研究的主要目的是评估PFT异常与COVID-19感染后HRQoL评分受损之间的任何相关性。
方法：这是对路易斯维尔前瞻性队列患者的分析，KY感染了COVID-19。收集的数据包括人口统计，既往病史,实验室测试,PFTs,和一些HRQoL问卷，如EuroQol5维度HRQoL问卷(EQ-5D-5L)，广义焦虑症7（GAD-7），患者健康问卷（PHQ-9），和DSM-5（PCL-5）的创伤后应激障碍检查表。进行了描述性统计，比较PFTs（正常与异常）和COVID-19感染后的时间（3个月vs6个月vs≥12个月）。
结果：FEV1、FVC、或COVID-19感染后一段时间内PFTs异常患者的百分比。在COVID-19之后，PFTs正常的患者的移动性HRQoL评分和GAD-7评分随时间的变化更严重。PFTs异常患者的任何HRQoL评分随时间变化均无差异。
结论：在PFT异常的患者中，通过EQ-5D-5L测量，与HRQoL评分没有时间关联，GAD-7、PHQ-9和PCL-5。在PFT正常的患者中，运动障碍和焦虑可能与COVID-19感染有关。COVID-19感染后，HRQoL评分的损害不能完全由肺活量测定异常的存在来解释.
方法：这是对路易斯维尔前瞻性队列患者的分析，KY感染了COVID-19。收集的数据包括人口统计，既往病史,实验室测试,PFTs,和一些HRQoL问卷，如EuroQol5维度HRQoL问卷(EQ-5D-5L)，广义焦虑症7（GAD-7），患者健康问卷（PHQ-9），和DSM-5（PCL-5）的创伤后应激障碍检查表。进行了描述性统计，比较PFTs（正常与异常）和COVID-19感染后的时间（3个月vs6个月vs≥12个月）。
结果：FEV1、FVC、或COVID-19感染后一段时间内PFTs异常患者的百分比。在COVID-19之后，PFTs正常的患者的移动性HRQoL评分和GAD-7评分随时间的变化更严重。PFTs异常患者的任何HRQoL评分随时间变化均无差异。
结论：在PFT异常的患者中，通过EQ-5D-5L测量，与HRQoL评分没有时间关联，GAD-7、PHQ-9和PCL-5。在PFT正常的患者中，运动障碍和焦虑可能与COVID-19感染有关。COVID-19感染后，HRQoL评分的损害不能完全由肺活量测定异常的存在来解释.
