Abstract：
Spinal cord injury (SCI) is a devastating neurological disorder, leading to loss of motor or somatosensory function, which is the most challenging worldwide medical problem. Re-establishment of intact neural circuits is the basis of spinal cord regeneration. Considering the crucial role of electrical signals in the nervous system, electroactive bioscaffolds have been widely developed for SCI repair. They can produce conductive pathways and a pro-regenerative microenvironment at the lesion site similar to that of the natural spinal cord, leading to neuronal regeneration and axonal growth, and functionally reactivating the damaged neural circuits. In this review, we first demonstrate the pathophysiological characteristics induced by SCI. Then, the crucial role of electrical signals in SCI repair is introduced. Based on a comprehensive analysis of these characteristics, recent advances in the electroactive bioscaffolds for SCI repair are summarized, focusing on both the conductive bioscaffolds and piezoelectric bioscaffolds, used independently or in combination with external electronic stimulation. Finally, thoughts on challenges and opportunities that may shape the future of bioscaffolds in SCI repair are concluded.
摘要：
脊髓损伤（SCI）是一种毁灭性的神经系统疾病，导致运动或体感功能丧失，这是全球最具挑战性的医疗问题。完整神经回路的重建是脊髓再生的基础。考虑到电信号在神经系统中的关键作用，电活性生物支架已被广泛用于SCI修复。它们可以在病变部位产生类似于天然脊髓的传导通路和促再生微环境，导致神经元再生和轴突生长，并在功能上重新激活受损的神经回路。在这次审查中,我们首先展示了SCI诱发的病理生理特征。然后，介绍了电信号在SCI修复中的重要作用。在综合分析这些特点的基础上,综述了近年来用于SCI修复的电活性生物支架的研究进展,专注于导电生物支架和压电生物支架，独立使用或与外部电子刺激结合使用。最后,总结了对可能塑造SCI修复中生物支架未来的挑战和机遇的思考。
