PDF(Pubmed)
Abstract：
BACKGROUND: The purpose of this study is to determine the significance of markers such as C-reactive protein, procalcitonin, complete blood count parameters, delta neutrophil index, ischemia-modified albumin, presepsin, and oxidative stress indicators, which are associated with inflammation, oxidative stress, and ischemia in the pathology and diagnosis of acute cholecystitis in adults.
METHODS: Patients diagnosed with acute cholecystitis in the emergency department and healthy individuals in the control group were included in the study. Routine blood count and biochemistry analyses were performed on the participants. Blood serum was used to measure ischemia-modified albumin, presepsin, and oxidative stress indicators.
RESULTS: White blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, delta neutrophil index, C-reactive protein, procalcitonin, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, presepsin, and oxidative stress indicators were significantly higher in patients with cholecystitis compared to the control group. Measurements of white blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and delta neutrophil index can be included as part of the complete blood count. The complete blood count parameters are readily available and do not incur additional costs to the healthcare system.
CONCLUSIONS: The authors believe that the neutrophil-to-lymphocyte ratio, delta neutrophil index, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, and presepsin values can be used as new markers in the diagnosis of acute cholecystitis due to their high sensitivity, specificity, and low negative likelihood ratio.
METHODS: Patients diagnosed with acute cholecystitis in the emergency department and healthy individuals in the control group were included in the study. Routine blood count and biochemistry analyses were performed on the participants. Blood serum was used to measure ischemia-modified albumin, presepsin, and oxidative stress indicators.
RESULTS: White blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, delta neutrophil index, C-reactive protein, procalcitonin, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, presepsin, and oxidative stress indicators were significantly higher in patients with cholecystitis compared to the control group. Measurements of white blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and delta neutrophil index can be included as part of the complete blood count. The complete blood count parameters are readily available and do not incur additional costs to the healthcare system.
CONCLUSIONS: The authors believe that the neutrophil-to-lymphocyte ratio, delta neutrophil index, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, and presepsin values can be used as new markers in the diagnosis of acute cholecystitis due to their high sensitivity, specificity, and low negative likelihood ratio.
摘要：
背景：这项研究的目的是确定C反应蛋白等标志物的意义，降钙素原,全血细胞计数参数,中性粒细胞指数,缺血修饰白蛋白，presepsin,和氧化应激指标，与炎症有关，氧化应激，和缺血在成人急性胆囊炎的病理和诊断中的应用。
方法：将急诊科诊断为急性胆囊炎的患者和对照组的健康个体纳入研究。对参与者进行常规血细胞计数和生化分析。血清用于测量缺血修饰白蛋白，presepsin,和氧化应激指标。
结果：白细胞计数，中性粒细胞与淋巴细胞的比率，血小板与淋巴细胞比率，中性粒细胞指数,C反应蛋白,降钙素原,缺血修饰白蛋白，缺血修饰的白蛋白与白蛋白之比，presepsin,胆囊炎患者的氧化应激指标明显高于对照组。白细胞计数的测量,中性粒细胞与淋巴细胞的比率，血小板与淋巴细胞比率，和delta中性粒细胞指数可以作为全血细胞计数的一部分。全血细胞计数参数是容易获得的,并且不会给医疗保健系统带来额外的成本。
结论：作者认为中性粒细胞与淋巴细胞的比率，中性粒细胞指数,缺血修饰白蛋白，缺血修饰的白蛋白与白蛋白之比，Presepsin值具有较高的敏感性,可作为诊断急性胆囊炎的新指标,特异性，和低的负似然比。
方法：将急诊科诊断为急性胆囊炎的患者和对照组的健康个体纳入研究。对参与者进行常规血细胞计数和生化分析。血清用于测量缺血修饰白蛋白，presepsin,和氧化应激指标。
结果：白细胞计数，中性粒细胞与淋巴细胞的比率，血小板与淋巴细胞比率，中性粒细胞指数,C反应蛋白,降钙素原,缺血修饰白蛋白，缺血修饰的白蛋白与白蛋白之比，presepsin,胆囊炎患者的氧化应激指标明显高于对照组。白细胞计数的测量,中性粒细胞与淋巴细胞的比率，血小板与淋巴细胞比率，和delta中性粒细胞指数可以作为全血细胞计数的一部分。全血细胞计数参数是容易获得的,并且不会给医疗保健系统带来额外的成本。
结论：作者认为中性粒细胞与淋巴细胞的比率，中性粒细胞指数,缺血修饰白蛋白，缺血修饰的白蛋白与白蛋白之比，Presepsin值具有较高的敏感性,可作为诊断急性胆囊炎的新指标,特异性，和低的负似然比。
