Abstract：
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of end-stage liver disease associated with increased mortality and cardiovascular disease. Obesity and diabetes are the most important risk factors of MASLD. It is well-established that obesity-associated insulin resistance leads to a situation of tissue lipotoxicity characterized by an accumulation of excess fat in non-fat tissues such as the liver, promoting the development of MASLD, and its progression into metabolic dysfunction-associated steatohepatitis.
METHODS: Here, we aimed to review the impact of disrupted intestinal permeability, antimicrobial proteins and bacterial endotoxin in the development and progression of MASLD.
CONCLUSIONS: Recent studies demonstrated that obesity- and obesogenic diets-associated alterations of intestinal microbiota along with the disruption of intestinal barrier integrity, the alteration in antimicrobial proteins and, in consequence, an enhanced translocation of bacterial endotoxin into bloodstream might contribute to this pathological process through to impacting liver metabolism and inflammation.
METHODS: Here, we aimed to review the impact of disrupted intestinal permeability, antimicrobial proteins and bacterial endotoxin in the development and progression of MASLD.
CONCLUSIONS: Recent studies demonstrated that obesity- and obesogenic diets-associated alterations of intestinal microbiota along with the disruption of intestinal barrier integrity, the alteration in antimicrobial proteins and, in consequence, an enhanced translocation of bacterial endotoxin into bloodstream might contribute to this pathological process through to impacting liver metabolism and inflammation.
摘要：
背景：代谢功能障碍相关的脂肪变性肝病（MASLD）是与死亡率和心血管疾病相关的终末期肝病的主要原因。肥胖和糖尿病是MASLD最重要的危险因素。公认的是，肥胖相关的胰岛素抵抗导致组织脂毒性的情况，其特征是在非脂肪组织（如肝脏）中积累过多的脂肪。促进MASLD的发展，以及其进展为代谢功能障碍相关的脂肪性肝炎。
方法：这里，我们的目的是回顾肠道通透性破坏的影响，抗菌蛋白和细菌内毒素在MASLD的发展和进展中的作用。
结论：最近的研究表明，肥胖和肥胖饮食与肠道菌群的改变以及肠道屏障完整性的破坏有关，抗菌蛋白的改变，因此，细菌内毒素向血液的转运增强可能通过影响肝脏代谢和炎症而导致这一病理过程。
方法：这里，我们的目的是回顾肠道通透性破坏的影响，抗菌蛋白和细菌内毒素在MASLD的发展和进展中的作用。
结论：最近的研究表明，肥胖和肥胖饮食与肠道菌群的改变以及肠道屏障完整性的破坏有关，抗菌蛋白的改变，因此，细菌内毒素向血液的转运增强可能通过影响肝脏代谢和炎症而导致这一病理过程。
