METHODS: Here, we aimed to review the impact of disrupted intestinal permeability, antimicrobial proteins and bacterial endotoxin in the development and progression of MASLD.
CONCLUSIONS: Recent studies demonstrated that obesity- and obesogenic diets-associated alterations of intestinal microbiota along with the disruption of intestinal barrier integrity, the alteration in antimicrobial proteins and, in consequence, an enhanced translocation of bacterial endotoxin into bloodstream might contribute to this pathological process through to impacting liver metabolism and inflammation.
方法:这里,我们的目的是回顾肠道通透性破坏的影响,抗菌蛋白和细菌内毒素在MASLD的发展和进展中的作用。
结论:最近的研究表明,肥胖和肥胖饮食与肠道菌群的改变以及肠道屏障完整性的破坏有关,抗菌蛋白的改变,因此,细菌内毒素向血液的转运增强可能通过影响肝脏代谢和炎症而导致这一病理过程。