Abstract：
UNASSIGNED: To analyze the effects of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) on the cognitive function of individuals with Alzheimer\'s disease (AD).
UNASSIGNED: This systematic review with meta-analysis and meta-regression included randomized clinical trials published until 05/2022. We included studies conducted with individuals with AD of both sexes, aged between 55 and 85 years, treated with tDCS, TMS, or both.
UNASSIGNED: Twenty-one studies were included in the systematic review and sixteen in the meta-analysis. Meta-regression suggested a significant influence of anodic tDCS with current intensity of 1.5 mA on cognitive function. Significant results were found with treatment frequencies of three and five days a week for two weeks. Subgroup analysis found that anodic tDCS influences cognitive function, regardless of AD stage. Similar was observed for TMS using a frequency of 20 Hz and current intensity of 90% of the resting motor threshold.
UNASSIGNED: Anodal tDCS and 20 Hz TMS have demonstrated the ability to improve cognitive function in AD by modulating neural activity. These therapies are safe and well-tolerated, offering promise as adjuncts to available pharmacological treatments. Studies with greater methodological rigor and parameter standardization are warranted. Comprehensive investigations involving neuroimaging techniques may provide a better understanding of the interaction between induced electrical fields and the complex neural networks affected in AD, paving the way for more personalized and effective neurostimulation approaches.
UNASSIGNED: This systematic review with meta-analysis and meta-regression included randomized clinical trials published until 05/2022. We included studies conducted with individuals with AD of both sexes, aged between 55 and 85 years, treated with tDCS, TMS, or both.
UNASSIGNED: Twenty-one studies were included in the systematic review and sixteen in the meta-analysis. Meta-regression suggested a significant influence of anodic tDCS with current intensity of 1.5 mA on cognitive function. Significant results were found with treatment frequencies of three and five days a week for two weeks. Subgroup analysis found that anodic tDCS influences cognitive function, regardless of AD stage. Similar was observed for TMS using a frequency of 20 Hz and current intensity of 90% of the resting motor threshold.
UNASSIGNED: Anodal tDCS and 20 Hz TMS have demonstrated the ability to improve cognitive function in AD by modulating neural activity. These therapies are safe and well-tolerated, offering promise as adjuncts to available pharmacological treatments. Studies with greater methodological rigor and parameter standardization are warranted. Comprehensive investigations involving neuroimaging techniques may provide a better understanding of the interaction between induced electrical fields and the complex neural networks affected in AD, paving the way for more personalized and effective neurostimulation approaches.
摘要：
■分析经颅直流电刺激（tDCS）和经颅磁刺激（TMS）对阿尔茨海默病（AD）患者认知功能的影响。
■这项具有荟萃分析和荟萃回归的系统评价包括截至2022年5月5日发表的随机临床试验。我们纳入了对男女AD患者进行的研究，年龄在55至85岁之间，用TDCS处理，TMS,或者两者兼而有之。
■21项研究纳入系统评价，16项纳入荟萃分析。Meta回归表明，电流强度为1.5mA的阳极tDCS对认知功能有显着影响。发现显着结果，治疗频率为每周三天和五天，持续两周。亚组分析发现，阳极tDCS影响认知功能，不管AD阶段。对于使用20Hz的频率和静止运动阈值的90%的电流强度的TMS观察到类似的。
■AnodaltDCS和20HzTMS已证明能够通过调节神经活动来改善AD中的认知功能。这些疗法是安全和耐受性良好的，提供承诺作为现有药物治疗的辅助手段。有必要进行更严格的方法和参数标准化的研究。涉及神经成像技术的综合调查可能会更好地了解感应电场与AD中受影响的复杂神经网络之间的相互作用。为更个性化和有效的神经刺激方法铺平道路。
■这项具有荟萃分析和荟萃回归的系统评价包括截至2022年5月5日发表的随机临床试验。我们纳入了对男女AD患者进行的研究，年龄在55至85岁之间，用TDCS处理，TMS,或者两者兼而有之。
■21项研究纳入系统评价，16项纳入荟萃分析。Meta回归表明，电流强度为1.5mA的阳极tDCS对认知功能有显着影响。发现显着结果，治疗频率为每周三天和五天，持续两周。亚组分析发现，阳极tDCS影响认知功能，不管AD阶段。对于使用20Hz的频率和静止运动阈值的90%的电流强度的TMS观察到类似的。
■AnodaltDCS和20HzTMS已证明能够通过调节神经活动来改善AD中的认知功能。这些疗法是安全和耐受性良好的，提供承诺作为现有药物治疗的辅助手段。有必要进行更严格的方法和参数标准化的研究。涉及神经成像技术的综合调查可能会更好地了解感应电场与AD中受影响的复杂神经网络之间的相互作用。为更个性化和有效的神经刺激方法铺平道路。
