Abstract：
The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell survival, growth, maturation, and differentiation factors that are important for the development and maintenance of hematopoietic cells and immune organs. Its dysregulation is associated with a number of immune pathologies and malignancies. Originally described as the signaling pathway that controls the NFκB family member RelB, we now know that noncanonical signaling also controls NFκB RelA and cRel. Here, we aim to clarify our understanding of the molecular network that mediates noncanonical NFκB signaling and review the human diseases that result from a deficient or hyper-active noncanonical NFκB pathway. It turns out that dysregulation of RelA and cRel, not RelB, is often implicated in mediating the resulting pathology. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Cancer > Molecular and Cellular Physiology Immune System Diseases > Stem Cells and Development.
摘要：
非经典NFκB信号通路介导多种细胞存活的生物学功能，增长,成熟,以及对造血细胞和免疫器官的发育和维持重要的分化因子。它的失调与许多免疫病理和恶性肿瘤有关。最初描述为控制NFκB家族成员RelB的信号通路，我们现在知道，非规范信号也控制NFκBRelA和cRel。这里,我们的目的是阐明我们对介导非规范NFκB信号传导的分子网络的理解,并回顾由缺陷或过度活跃的非规范NFκB通路引起的人类疾病.事实证明，RelA和cRel的失调，不是RelB,通常与介导所产生的病理有关。本文分为：免疫系统疾病>分子和细胞生理学癌症>分子和细胞生理学免疫系统疾病>干细胞和发育。
