PDF(Pubmed)
Abstract：
UNASSIGNED: To analyze the time trends in the notification rates of registered tuberculosis (TB) and bacteriologically confirmed TB in Shandong Province. And analyze the changes in TB treatment outcomes during 2005-2021.
UNASSIGNED: The information of TB patients registered in the Shandong Information Center for Disease Control and Prevention (CDC) was collected during 2005-2021. We calculated the notification rates of registered TB and bacteriologically confirmed TB. Moreover, we calculated the year-to-year change rate of TB in treatment outcomes before and after COVID-19. The time trends were analyzed using the joinpoint regression method and illustrated as the annual percentage change (APC) of notification rates.
UNASSIGNED: A total of 236,898 cases of TB were diagnosed during 2005-2021, of which 51.11% were bacteriologically confirmed cases. Since 2008, the notification rates of registered TB have declined. The notification rates of bacteriologically confirmed TB had been declining during 2005-2016, then remained stable after 2016. In subgroup, the notification rates of both registered TB and bacteriologically confirmed TB were higher among men, rural residents, and people aged ≥ 60 years. Compared with clinically confirmed TB, bacteriologically confirmed TB has shown higher rates of poor outcomes since 2008 and higher case fatality rate since 2005. The rate of poor outcomes remained stable during 2008-2019. However, after the COVID-19 outbreak, the rate of poor outcomes and case fatality rate of TB has risen significantly.
UNASSIGNED: After unremitting efforts to fight against TB, the notification rates of registered TB and bacteriologically confirmed TB declined in Shandong Province. The rate of poor outcomes remained stable during 2008-2019, then rise significantly after the COVID-19 outbreak. In the context of the long-term existence of COVID-19, further efforts should be made in TB diagnosis and treatment among high-risk population, especially with regard to males, rural residents and older adults.
UNASSIGNED: The information of TB patients registered in the Shandong Information Center for Disease Control and Prevention (CDC) was collected during 2005-2021. We calculated the notification rates of registered TB and bacteriologically confirmed TB. Moreover, we calculated the year-to-year change rate of TB in treatment outcomes before and after COVID-19. The time trends were analyzed using the joinpoint regression method and illustrated as the annual percentage change (APC) of notification rates.
UNASSIGNED: A total of 236,898 cases of TB were diagnosed during 2005-2021, of which 51.11% were bacteriologically confirmed cases. Since 2008, the notification rates of registered TB have declined. The notification rates of bacteriologically confirmed TB had been declining during 2005-2016, then remained stable after 2016. In subgroup, the notification rates of both registered TB and bacteriologically confirmed TB were higher among men, rural residents, and people aged ≥ 60 years. Compared with clinically confirmed TB, bacteriologically confirmed TB has shown higher rates of poor outcomes since 2008 and higher case fatality rate since 2005. The rate of poor outcomes remained stable during 2008-2019. However, after the COVID-19 outbreak, the rate of poor outcomes and case fatality rate of TB has risen significantly.
UNASSIGNED: After unremitting efforts to fight against TB, the notification rates of registered TB and bacteriologically confirmed TB declined in Shandong Province. The rate of poor outcomes remained stable during 2008-2019, then rise significantly after the COVID-19 outbreak. In the context of the long-term existence of COVID-19, further efforts should be made in TB diagnosis and treatment among high-risk population, especially with regard to males, rural residents and older adults.
摘要：
■分析山东省登记结核病（TB）和细菌学确诊结核病通报率的时间趋势。并分析2005-2021年期间结核病治疗结果的变化。
■在山东省疾病预防控制中心（CDC）注册的结核病患者的信息是在2005-2021年期间收集的。我们计算了登记结核病和细菌学确认结核病的通报率。此外，我们计算了COVID-19前后结核病治疗结局的逐年变化率.使用连接点回归方法分析了时间趋势，并以通知率的年度百分比变化（APC）表示。
■在2005-2021年期间，共诊断出236,898例结核病，其中51.11％为细菌学确诊病例。自2008年以来，登记结核病的通报率有所下降。在2005-2016年期间，细菌学确认的结核病的通报率一直在下降，然后在2016年之后保持稳定。在子组中，登记结核病和细菌学确诊结核病的通报率在男性中都较高，农村居民,和年龄≥60岁的人。与临床确诊的结核病相比，自2008年以来，经细菌学证实的结核病的不良结局率较高，自2005年以来，病死率较高。2008-2019年期间，不良后果率保持稳定。然而,在COVID-19爆发后，结核病的不良结局率和病死率显著上升.
■经过与结核病的不懈努力，山东省登记结核病和细菌学确诊结核病的通报率有所下降。2008-2019年期间，不良后果率保持稳定，然后在COVID-19爆发后显著上升。在COVID-19长期存在的背景下，应进一步努力在高危人群中进行结核病诊断和治疗，尤其是男性,农村居民和老年人。
■在山东省疾病预防控制中心（CDC）注册的结核病患者的信息是在2005-2021年期间收集的。我们计算了登记结核病和细菌学确认结核病的通报率。此外，我们计算了COVID-19前后结核病治疗结局的逐年变化率.使用连接点回归方法分析了时间趋势，并以通知率的年度百分比变化（APC）表示。
■在2005-2021年期间，共诊断出236,898例结核病，其中51.11％为细菌学确诊病例。自2008年以来，登记结核病的通报率有所下降。在2005-2016年期间，细菌学确认的结核病的通报率一直在下降，然后在2016年之后保持稳定。在子组中，登记结核病和细菌学确诊结核病的通报率在男性中都较高，农村居民,和年龄≥60岁的人。与临床确诊的结核病相比，自2008年以来，经细菌学证实的结核病的不良结局率较高，自2005年以来，病死率较高。2008-2019年期间，不良后果率保持稳定。然而,在COVID-19爆发后，结核病的不良结局率和病死率显著上升.
■经过与结核病的不懈努力，山东省登记结核病和细菌学确诊结核病的通报率有所下降。2008-2019年期间，不良后果率保持稳定，然后在COVID-19爆发后显著上升。在COVID-19长期存在的背景下，应进一步努力在高危人群中进行结核病诊断和治疗，尤其是男性,农村居民和老年人。
