PDF(Pubmed)
Abstract：
Introduction The purpose of this study was to determine the prevalence of ventricular tachycardia (VT) among patients admitted with peripartum cardiomyopathy (PPCM) as well as to analyze the independent association of VT with in-hospital outcomes among PPCM patients. Methods Data were obtained from the National Inpatient Sample from January 2016 to December 2019. We assessed predictors of VT in patients admitted with PPCM. We also assessed the independent association of VT with clinical outcomes among patients admitted with PPCM. Results From 2016 to 2019, 4730 patients with PPCM were reported to the national inpatient sample database, 309 of which developed VT (6.5%). Using multivariate analysis, we found predictors of VT to include patient characteristics and factors such as age (adjusted OR (aOR)=1.020, p=0.023), chronic kidney disease (aOR=1.440, p=0.048), coagulopathy (aOR=1.964, p=0.006), and atrial fibrillation (aOR=3.965, p<0.001). Conversely, pre-eclampsia was significantly associated with a decreased risk of VT in PPCM patients (aOR=0.218, p=0.001). Conclusion In a large cohort of patients admitted with peripartum cardiomyopathy, we found the prevalence of VT to be 6.5%. Risk factors for VT in this patient population included conditions such as coagulopathy and atrial fibrillation.
摘要：
本研究的目的是确定围生期心肌病（PPCM）患者室性心动过速（VT）的患病率，并分析PPCM患者中VT与院内预后的独立关联。方法数据来自2016年1月至2019年12月的全国住院患者样本。我们评估了PPCM患者的VT预测因子。我们还评估了PPCM患者室性心动过速与临床预后的独立关联。结果2016年至2019年，全国住院样本数据库报告了4730例PPCM患者，其中309例发生室性心动过速（6.5%）。使用多变量分析，我们发现室性心动过速的预测因素包括患者特征和年龄等因素(校正OR(aOR)=1.020,p=0.023),慢性肾脏病（aOR=1.440，p=0.048），凝血功能障碍（aOR=1.964，p=0.006），房颤(aOR=3.965,p<0.001)。相反，PPCM患者子痫前期与VT风险降低显著相关(aOR=0.218,p=0.001).结论在大量围产期心肌病患者中，我们发现VT的患病率为6.5%.该患者群中室性心动过速的危险因素包括凝血病和心房颤动等疾病。
