PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to explore the association between the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT ratio) and diabetic retinopathy (DR) in patients with type 2 diabetes.
UNASSIGNED: In this cross-sectional study, clinical data from 3002 patients with type 2 diabetes admitted to the Department of Endocrinology of our hospital between January 1, 2021, and December 1, 2022, were retrospectively collected. Measurements of AST and ALT were conducted and diabetes-related complications were screened. The association between AST/ALT ratio and diabetic retinopathy was assessed using multivariate logistic regression, and a generalized additive model (GAM) was used to investigate nonlinear relationships. Subgroup analyses and interaction tests were also conducted.
UNASSIGNED: Among the 3002 patients, 1590 (52.96%) were male and 1412 (47.04%) were female. The mean AST/ALT ratio was 0.98 ± 0.32, ranging from 0.37 (Min) to 2.17 (Max). Diabetic retinopathy was present in 40.47% of the patients. After multivariate adjustments, for each 0.1 unit increase in AST/ALT ratio, the risk of DR increased by 4% (OR = 1.04, 95% CI: 1.01-1.07, p=0.0053). Higher AST/ALT ratio quartiles were associated with Higher prevalence of DR (OR vs. Q1: Q4 = 1.34 (CI: 1.03-1.75, p=0.0303).The GAM and smoothed curve fit indicated a linear relationship between AST/ALT ratio and DR risk, with no significant interaction effects across different subgroups.
UNASSIGNED: Our study demonstrates a positive correlation between the AST/ALT ratio and diabetic retinopathy risk in type 2 diabetes, suggesting its potential role in assessing DR risk.
UNASSIGNED: In this cross-sectional study, clinical data from 3002 patients with type 2 diabetes admitted to the Department of Endocrinology of our hospital between January 1, 2021, and December 1, 2022, were retrospectively collected. Measurements of AST and ALT were conducted and diabetes-related complications were screened. The association between AST/ALT ratio and diabetic retinopathy was assessed using multivariate logistic regression, and a generalized additive model (GAM) was used to investigate nonlinear relationships. Subgroup analyses and interaction tests were also conducted.
UNASSIGNED: Among the 3002 patients, 1590 (52.96%) were male and 1412 (47.04%) were female. The mean AST/ALT ratio was 0.98 ± 0.32, ranging from 0.37 (Min) to 2.17 (Max). Diabetic retinopathy was present in 40.47% of the patients. After multivariate adjustments, for each 0.1 unit increase in AST/ALT ratio, the risk of DR increased by 4% (OR = 1.04, 95% CI: 1.01-1.07, p=0.0053). Higher AST/ALT ratio quartiles were associated with Higher prevalence of DR (OR vs. Q1: Q4 = 1.34 (CI: 1.03-1.75, p=0.0303).The GAM and smoothed curve fit indicated a linear relationship between AST/ALT ratio and DR risk, with no significant interaction effects across different subgroups.
UNASSIGNED: Our study demonstrates a positive correlation between the AST/ALT ratio and diabetic retinopathy risk in type 2 diabetes, suggesting its potential role in assessing DR risk.
摘要：
■本研究旨在探讨2型糖尿病患者谷草转氨酶与谷丙转氨酶比值(AST/ALT比值)与糖尿病视网膜病变(DR)之间的关系。
■在这项横断面研究中，回顾性收集2021年1月1日至2022年12月1日在我院内分泌科收治的3002例2型糖尿病患者的临床资料.进行AST和ALT的测量并筛选糖尿病相关并发症。AST/ALT比值与糖尿病视网膜病变之间的关联使用多变量逻辑回归进行评估，并使用广义加性模型(GAM)来研究非线性关系。还进行了亚组分析和相互作用测试。
■在3002名患者中，男性1590人(52.96%),女性1412人(47.04%)。平均AST/ALT比值为0.98±0.32,范围为0.37(Min)至2.17(Max)。40.47％的患者存在糖尿病性视网膜病变。经过多变量调整后，AST/ALT比率每增加0.1个单位，DR风险增加4%(OR=1.04,95%CI:1.01-1.07,p=0.0053)。较高的AST/ALT比值四分位数与较高的DR患病率相关（OR与Q1：Q4=1.34（CI：1.03-1.75，p=0.0303）。GAM和平滑曲线拟合表明AST/ALT比值与DR风险之间呈线性关系，不同亚组之间没有显著的交互作用。
■我们的研究表明，在2型糖尿病患者中，AST/ALT比值与糖尿病视网膜病变风险呈正相关。提示其在评估DR风险中的潜在作用。
■在这项横断面研究中，回顾性收集2021年1月1日至2022年12月1日在我院内分泌科收治的3002例2型糖尿病患者的临床资料.进行AST和ALT的测量并筛选糖尿病相关并发症。AST/ALT比值与糖尿病视网膜病变之间的关联使用多变量逻辑回归进行评估，并使用广义加性模型(GAM)来研究非线性关系。还进行了亚组分析和相互作用测试。
■在3002名患者中，男性1590人(52.96%),女性1412人(47.04%)。平均AST/ALT比值为0.98±0.32,范围为0.37(Min)至2.17(Max)。40.47％的患者存在糖尿病性视网膜病变。经过多变量调整后，AST/ALT比率每增加0.1个单位，DR风险增加4%(OR=1.04,95%CI:1.01-1.07,p=0.0053)。较高的AST/ALT比值四分位数与较高的DR患病率相关（OR与Q1：Q4=1.34（CI：1.03-1.75，p=0.0303）。GAM和平滑曲线拟合表明AST/ALT比值与DR风险之间呈线性关系，不同亚组之间没有显著的交互作用。
■我们的研究表明，在2型糖尿病患者中，AST/ALT比值与糖尿病视网膜病变风险呈正相关。提示其在评估DR风险中的潜在作用。
