PDF(Pubmed)
Abstract：
UNASSIGNED: Tamoxifen is a drug that has been used extensively as a chemotherapeutic agent for breast cancer. It should be taken for a long period, from few weeks up to many years, so it can induce gynecological and nongynecological complications.
UNASSIGNED: Present study was conducted to clarify the histopathological effects of tamoxifen intake on the ovarian follicles of rats and evaluate the promising recovery after drug withdrawal.
UNASSIGNED: Adult female albino rats (n = 24) were randomly divided into four groups. Group I: Control rats without treatment. Group II: Rats received olive oil vehicle. Group III: Rats received 5 mg/kg daily of tamoxifen dissolved in olive oil by oral administration for 4 weeks. Group IV: Rats received tamoxifen as in Group III then will be kept for another 4 weeks without treatment for recovery. Then, the rats were anaesthetized and the ovaries were removed and prepared for histological assessment by light microscope.
UNASSIGNED: The ovarian histological findings in the ovary of Group III revealed an increase in atretic ovarian follicles, appearance of cystic ovarian follicles, and cystic corpus luteum. The granulosa cells of ovarian follicles were disorganized with vacuolation of their cytoplasm, increased number of pyknotic nuclei, fragmented nuclei, and apoptotic bodies. After the withdrawal of drug, the ovarian tissue showed slight improvement with the appearance of some atretic follicles with degenerated oocyte and stromal hyperplasia.
UNASSIGNED: Based on the results, tamoxifen induced marked histological changes in the ovary. If tamoxifen is mandatory for the prevention of breast cancer, frequent gynecological examination should be carried out to detect any side effects.
UNASSIGNED: Present study was conducted to clarify the histopathological effects of tamoxifen intake on the ovarian follicles of rats and evaluate the promising recovery after drug withdrawal.
UNASSIGNED: Adult female albino rats (n = 24) were randomly divided into four groups. Group I: Control rats without treatment. Group II: Rats received olive oil vehicle. Group III: Rats received 5 mg/kg daily of tamoxifen dissolved in olive oil by oral administration for 4 weeks. Group IV: Rats received tamoxifen as in Group III then will be kept for another 4 weeks without treatment for recovery. Then, the rats were anaesthetized and the ovaries were removed and prepared for histological assessment by light microscope.
UNASSIGNED: The ovarian histological findings in the ovary of Group III revealed an increase in atretic ovarian follicles, appearance of cystic ovarian follicles, and cystic corpus luteum. The granulosa cells of ovarian follicles were disorganized with vacuolation of their cytoplasm, increased number of pyknotic nuclei, fragmented nuclei, and apoptotic bodies. After the withdrawal of drug, the ovarian tissue showed slight improvement with the appearance of some atretic follicles with degenerated oocyte and stromal hyperplasia.
UNASSIGNED: Based on the results, tamoxifen induced marked histological changes in the ovary. If tamoxifen is mandatory for the prevention of breast cancer, frequent gynecological examination should be carried out to detect any side effects.
摘要：
■他莫昔芬是一种已被广泛用作乳腺癌化疗药物的药物。应该花很长时间，从几周到很多年，所以它可以诱发妇科和非妇科并发症。
■进行本研究以阐明他莫昔芬摄入对大鼠卵巢卵泡的组织病理学影响，并评估停药后有希望的恢复。
■成年雌性白化大鼠（n=24）随机分为四组。I组:对照大鼠,不经处理。组II:大鼠接受橄榄油载体。组III:大鼠通过口服施用每天5mg/kg溶解在橄榄油中的他莫昔芬,持续4周。IV组:如III组接受他莫昔芬的大鼠,然后再保持4周,不进行治疗以恢复。然后，将大鼠麻醉,摘除卵巢,准备通过光学显微镜进行组织学评估.
■第三组卵巢的卵巢组织学发现显示闭锁性卵巢卵泡增加，囊性卵泡的外观，和囊性黄体。卵巢卵泡的颗粒细胞因细胞质空泡而杂乱无章，固缩核数量增加，破碎的核，和凋亡体。停药后,卵巢组织略有改善，出现了一些闭锁性卵泡，卵母细胞变性和基质增生。
■根据结果，他莫昔芬诱导卵巢明显的组织学变化。如果他莫昔芬是预防乳腺癌的强制性药物，应经常进行妇科检查以发现任何副作用。
■进行本研究以阐明他莫昔芬摄入对大鼠卵巢卵泡的组织病理学影响，并评估停药后有希望的恢复。
■成年雌性白化大鼠（n=24）随机分为四组。I组:对照大鼠,不经处理。组II:大鼠接受橄榄油载体。组III:大鼠通过口服施用每天5mg/kg溶解在橄榄油中的他莫昔芬,持续4周。IV组:如III组接受他莫昔芬的大鼠,然后再保持4周,不进行治疗以恢复。然后，将大鼠麻醉,摘除卵巢,准备通过光学显微镜进行组织学评估.
■第三组卵巢的卵巢组织学发现显示闭锁性卵巢卵泡增加，囊性卵泡的外观，和囊性黄体。卵巢卵泡的颗粒细胞因细胞质空泡而杂乱无章，固缩核数量增加，破碎的核，和凋亡体。停药后,卵巢组织略有改善，出现了一些闭锁性卵泡，卵母细胞变性和基质增生。
■根据结果，他莫昔芬诱导卵巢明显的组织学变化。如果他莫昔芬是预防乳腺癌的强制性药物，应经常进行妇科检查以发现任何副作用。
