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Abstract：
UNASSIGNED: The study aims to categorize malignant small round cell tumors (MSRCTs) originating in various sites of the body with the objective of utilization of cytomorphological features and ancillary techniques.
UNASSIGNED: It is a cross-sectional study conducted over a time span of 3 years (2017-2020). 33 cases of tumors with round cell morphology were evaluated by fine needle aspiration cytology (FNAC).
UNASSIGNED: The application of cell block preparation supported by immunohistochemistry aided in the categorization of 23 cases with definite diagnosis and the rest were reported as MSRCTs.
UNASSIGNED: Among the categorized 23/33 cases, the most common diagnosis was Ewing\'s sarcoma (7/23) followed by 6 cases of lymphoma. There were 2 cases each of rhabdomyosarcoma and Langerhans cell histiocytosis (LCH) and 1 case each of neuroblastoma, desmoplastic small round cell tumor (DSRCT), myeloid sarcoma, neuroendocrine tumor of pancreas, plasmacytoma, and small cell carcinoma. Histopathology confirmation was available in 24/33 cases. Among the categorized tumors (23/33), biopsy correlation was available in 19 cases, of which concordant result was seen in 17 cases (89.47%), which were 6 cases of lymphoma, 5 cases of Ewing\'s sarcoma (EWS), 2 of rhabdomyosarcoma, and 1 each of neuroblastoma, small cell carcinoma, DSRCT, and LCH. Discordant result was seen in one case of rhabdomyosarcoma and a case of synovial sarcoma reported as extraskeletal EWS in cytology. Out of the uncategorized cases reported as MSRTCs, histopathology was available in 5 cases which were diagnosed as rhabdomyosarcoma (1 cases), lymphoma (1 case), amelanotic melanoma (1 case), and extraskeletal EWS (2 cases).
UNASSIGNED: Categorization of MSRCTs should be done to implement appropriate therapeutic protocol. FNAC provides a rapid diagnosis contributing immensely for the timely management of the patient. Detailed cytomorphological evaluation serves as a guide for further evaluation by ancillary techniques leading to definitive diagnosis.
UNASSIGNED: It is a cross-sectional study conducted over a time span of 3 years (2017-2020). 33 cases of tumors with round cell morphology were evaluated by fine needle aspiration cytology (FNAC).
UNASSIGNED: The application of cell block preparation supported by immunohistochemistry aided in the categorization of 23 cases with definite diagnosis and the rest were reported as MSRCTs.
UNASSIGNED: Among the categorized 23/33 cases, the most common diagnosis was Ewing\'s sarcoma (7/23) followed by 6 cases of lymphoma. There were 2 cases each of rhabdomyosarcoma and Langerhans cell histiocytosis (LCH) and 1 case each of neuroblastoma, desmoplastic small round cell tumor (DSRCT), myeloid sarcoma, neuroendocrine tumor of pancreas, plasmacytoma, and small cell carcinoma. Histopathology confirmation was available in 24/33 cases. Among the categorized tumors (23/33), biopsy correlation was available in 19 cases, of which concordant result was seen in 17 cases (89.47%), which were 6 cases of lymphoma, 5 cases of Ewing\'s sarcoma (EWS), 2 of rhabdomyosarcoma, and 1 each of neuroblastoma, small cell carcinoma, DSRCT, and LCH. Discordant result was seen in one case of rhabdomyosarcoma and a case of synovial sarcoma reported as extraskeletal EWS in cytology. Out of the uncategorized cases reported as MSRTCs, histopathology was available in 5 cases which were diagnosed as rhabdomyosarcoma (1 cases), lymphoma (1 case), amelanotic melanoma (1 case), and extraskeletal EWS (2 cases).
UNASSIGNED: Categorization of MSRCTs should be done to implement appropriate therapeutic protocol. FNAC provides a rapid diagnosis contributing immensely for the timely management of the patient. Detailed cytomorphological evaluation serves as a guide for further evaluation by ancillary techniques leading to definitive diagnosis.
摘要：
■该研究旨在利用细胞形态学特征和辅助技术对起源于身体各个部位的恶性小圆细胞肿瘤（MSRCT）进行分类。
■它是一项横断面研究，历时3年（2017-2020年）。采用细针穿刺细胞学（FNAC）对33例肿瘤进行圆形细胞形态评估。
■应用免疫组织化学支持的细胞块制备辅助分类23例明确诊断，其余为MSRCT。
■在23/33分类病例中，最常见的诊断是尤因肉瘤（7/23），其次是淋巴瘤6例。横纹肌肉瘤和朗格汉斯细胞组织细胞增生症(LCH)各2例,神经母细胞瘤各1例,促纤维增生性小圆细胞瘤(DSRCT),骨髓肉瘤,胰腺神经内分泌肿瘤,浆细胞瘤,和小细胞癌。24/33例有组织病理学证实。在分类的肿瘤中（23/33），19例活检相关性可用，其中17例(89.47%)结果一致，其中6例淋巴瘤，尤因肉瘤（EWS）5例，2例横纹肌肉瘤，和1个神经母细胞瘤，小细胞癌,DSRCT,和LCH。在细胞学中，在1例横纹肌肉瘤和1例滑膜肉瘤中发现了不一致的结果。在报告为MSRTC的未分类病例中，5例诊断为横纹肌肉瘤（1例），淋巴瘤（1例），无色素性黑色素瘤（1例），和骨外EWS（2例）。
■应进行MSRCT分类以实施适当的治疗方案。FNAC提供了快速诊断，为患者的及时管理做出了巨大贡献。详细的细胞形态学评估可作为辅助技术进一步评估的指南，从而导致明确的诊断。
■它是一项横断面研究，历时3年（2017-2020年）。采用细针穿刺细胞学（FNAC）对33例肿瘤进行圆形细胞形态评估。
■应用免疫组织化学支持的细胞块制备辅助分类23例明确诊断，其余为MSRCT。
■在23/33分类病例中，最常见的诊断是尤因肉瘤（7/23），其次是淋巴瘤6例。横纹肌肉瘤和朗格汉斯细胞组织细胞增生症(LCH)各2例,神经母细胞瘤各1例,促纤维增生性小圆细胞瘤(DSRCT),骨髓肉瘤,胰腺神经内分泌肿瘤,浆细胞瘤,和小细胞癌。24/33例有组织病理学证实。在分类的肿瘤中（23/33），19例活检相关性可用，其中17例(89.47%)结果一致，其中6例淋巴瘤，尤因肉瘤（EWS）5例，2例横纹肌肉瘤，和1个神经母细胞瘤，小细胞癌,DSRCT,和LCH。在细胞学中，在1例横纹肌肉瘤和1例滑膜肉瘤中发现了不一致的结果。在报告为MSRTC的未分类病例中，5例诊断为横纹肌肉瘤（1例），淋巴瘤（1例），无色素性黑色素瘤（1例），和骨外EWS（2例）。
■应进行MSRCT分类以实施适当的治疗方案。FNAC提供了快速诊断，为患者的及时管理做出了巨大贡献。详细的细胞形态学评估可作为辅助技术进一步评估的指南，从而导致明确的诊断。
