PDF(Pubmed)
Abstract：
The sudden outbreak of coronavirus disease 2019 (COVID-19) in early 2020 posed a massive threat to human life and caused an economic upheaval worldwide. Kidney transplant recipients (KTRs) became susceptible to infection during the COVID-19 pandemic owing to their use of immunosuppressants, resulting in increased hospitalization and mortality rates. Although the current epidemic situation is alleviated, the long-term existence of COVID-19 still seriously threatens the life and health of KTRs with low immunity. The Omicron variant, a highly infectious but less-pathogenic strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised concerns among transplant physicians regarding managing KTRs diagnosed with this variant. However, currently, there are no clear and unified guidelines for caring for KTRs infected with this variant. Therefore, we aimed to summarize the ongoing research on drugs that can treat Omicron variant infections in KTRs and explore the potential of adjusting immunotherapy strategies to enhance their responsiveness to vaccines. Herein, we discuss the situation of KTRs since the emergence of COVID-19 and focus on various prevention and treatment strategies for KTRs since the Omicron variant outbreak. We hope to assist physicians in managing KTRs in the presence of long-term COVID-19 variants.
摘要：
2020年初2019年冠状病毒病（COVID-19）的突然爆发对人类生命构成了巨大威胁，并在全球范围内造成了经济动荡。肾移植受者（KTR）在COVID-19大流行期间由于使用免疫抑制剂而变得容易感染，导致住院率和死亡率增加。虽然目前疫情有所缓解,COVID-19的长期存在仍然严重威胁着免疫力低下的KTRs的生命和健康。Omicron变体，严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）的高传染性但致病性较低的菌株，引起移植医生对管理诊断为这种变异的KTR的担忧。然而,目前,对于感染该变种的KTRs,目前尚无明确统一的护理指南.因此,我们旨在总结目前对可治疗KTRs中Omicron变异型感染的药物的研究,并探讨调整免疫治疗策略以增强其对疫苗反应性的潜力.在这里，我们讨论了自COVID-19出现以来KTRs的情况，并重点讨论了自Omicron变种爆发以来KTRs的各种预防和治疗策略。我们希望在存在长期COVID-19变异的情况下帮助医生管理KTR。
