UNASSIGNED: An important objective of this work was to give a full account of the clinical, pathological, and immune-histochemical features of several skin tumors in dogs.
UNASSIGNED: This study was a case series in the hospital clinic, Faculty of Veterinary Medicine, Zagazig University, Egypt. Twenty-five dogs (14 males and 11 females) were examined clinically during the period from March 2022 to October 2023. The skin swelling was collected from affected animals and then subjected to a detailed histopathological study to record the different gross and microscopic findings and confirm the diagnosis by immunohistochemistry.
UNASSIGNED: Skin neoplasia in dogs was exposed to various clinical signs, and the dogs\' ages ranged between 3 and 11 years. Concerning tumor features, the majority of neoplasms were malignant (65.52%) more than benign (34.48%). The study revealed the presence of 29 cases of dogs showed neoplasia with different prevalence rates including squamous cell carcinoma (13.79%), mast cell tumor (6.89%), basal cell tumors (10.34%), histiocytoma (6.89%), trichoepithelioma (10.34%), transmissible venereal tumor (10.34%), trichilemmoma (3.44%), scalp paraganglioma (3.44%), pilomatricoma (10.34%), malignant melanomas (17.24%), and miscellaneous cases as fat necrosis (6.89%), in males and females dogs with different histopathological lesions and immunohistochemistry expressions for pan-cytokeratin (CK), melanocyte-differentiation antigens (S100 protein), and synaptophysin.
UNASSIGNED: Malignant melanomas (17.24%) are the extremely common cutaneous tumors diagnosed in this study. Meanwhile, benign tumors such as trichilemmoma, trichoepithelioma, pilomatricoma, and paraganglioma are less frequent in dogs.
■这项工作的一个重要目标是全面介绍临床,病态,和几种狗皮肤肿瘤的免疫组织化学特征。
■这项研究是医院诊所的一个案例系列,兽医学院,扎加齐格大学,埃及。在2022年3月至2023年10月期间,对25只狗(14只雄性和11只雌性)进行了临床检查。从受影响的动物收集皮肤肿胀,然后进行详细的组织病理学研究,以记录不同的总体和微观发现,并通过免疫组织化学确认诊断。
■狗的皮肤瘤形成暴露于各种临床症状,狗的年龄在3到11岁之间。关于肿瘤特征,大多数肿瘤的恶性(65.52%)高于良性(34.48%)。研究发现29例犬存在瘤形成,患病率不同,包括鳞状细胞癌(13.79%),肥大细胞瘤(6.89%),基底细胞肿瘤(10.34%),组织细胞瘤(6.89%),毛发上皮瘤(10.34%),传染性性病瘤(10.34%),三毛鞘瘤(3.44%),头皮副神经节瘤(3.44%),毛囊瘤(10.34%),恶性黑色素瘤(17.24%),和其他病例为脂肪坏死(6.89%),在具有不同组织病理学病变和全细胞角蛋白(CK)的免疫组织化学表达的雄性和雌性犬中,黑素细胞分化抗原(S100蛋白),和突触素。
■恶性黑素瘤(17.24%)是本研究中最常见的皮肤肿瘤。同时,良性肿瘤如毛癣瘤,毛发上皮瘤,pilomatricoma,副神经节瘤在狗中的发病率较低。