PDF(Pubmed)
Abstract：
COVID-19 infection has been a significant contributor to global morbidity and mortality, especially among those patients with chronic diseases. The Centers for Disease Control and Prevention have classified sickle cell disease (SCD) as a condition that increases the risk of severe illness from COVID-19 infection. A retrospective study was conducted using the TRiNetX health research network database to identify SCA patients ( HbSS, Sbeta-thalassemia zero) who had SARS-CoV-2 infection over 2 years; these were compared with similar patients who did not have the infection in terms of demographics, pain control, and laboratory parameters COVID-19 illness impacts [ain crises and ACS, and prior vaccination against influenza and COVID-19 may represent a protective factor for developing pain crises.
摘要：
COVID-19感染是全球发病率和死亡率的重要因素，尤其是那些慢性病患者。疾病控制和预防中心将镰状细胞病(SCD)归类为增加COVID-19感染导致严重疾病风险的疾病。使用TRiNetX健康研究网络数据库进行了一项回顾性研究，以识别SCA患者（HbSS，Sβ-地中海贫血零）在2年内感染了SARS-CoV-2；将这些患者与人口统计学上没有感染的类似患者进行比较，疼痛控制,和实验室参数COVID-19疾病影响[在危机和ACS，先前接种过流感和COVID-19疫苗可能是发生疼痛危机的保护因素。
