METHODS: Forty-nine eyes from 35 patients with a history of DME were enrolled. Reading performance was assessed using the Radner reading charts, which include standardized sentences with geometrically progressing print sizes. Structural alterations in the inner and outer retina, as well as the retinal pigment epithelium (RPE), were graded based on OCT images.
RESULTS: Reading performance, measured as maximum reading speed, was associated with specific retinal biomarkers. The disruption of the ellipsoid zone (EZ) in the parafoveal region and the presence of disorganization of the inner retinal layers (DRIL) in the parafovea were correlated with reduced reading speed. These associations were independent of the presence of intraretinal or subretinal fluid.
CONCLUSIONS: Understanding the relationship between retinal biomarkers and reading performance could contribute to a comprehensive evaluation of visual function and quality of life in patients with DME, leading to better management strategies and treatment outcomes.
方法:纳入35例有DME病史患者的49只眼。使用Radner阅读图表评估阅读性能,其中包括具有几何尺寸的标准化句子。内外视网膜的结构改变,以及视网膜色素上皮(RPE),根据OCT图像进行分级。
结果:阅读性能,以最大读取速度测量,与特定的视网膜生物标志物相关。旁凹区域椭圆体区(EZ)的破坏和旁凹视网膜内层(DRIL)的混乱与阅读速度降低有关。这些关联与视网膜内或视网膜下液的存在无关。
结论:了解视网膜生物标志物与阅读能力之间的关系有助于全面评估DME患者的视功能和生活质量,导致更好的管理策略和治疗结果。