Abstract：
BACKGROUND: Vitiligo is characterized by depigmented patches resulting from loss of melanocytes. Phototherapy has emerged as a prominent treatment option for vitiligo, utilizing various light modalities to induce disease stability and repigmentation.
OBJECTIVE: This narrative review aims to explore the clinical applications and molecular mechanisms of phototherapy in vitiligo.
CONCLUSIONS: The review evaluates existing literature on phototherapy for vitiligo, analyzing studies on hospital-based and home-based phototherapy, as well as outcomes related to stabilization and repigmentation. Narrowband ultra-violet B, that is, NBUVB remains the most commonly employed, studied and effective phototherapy modality for vitiligo. Special attention is given to assessing different types of lamps, dosimetry, published guidelines, and the utilization of targeted phototherapy modalities. Additionally, the integration of phototherapy with other treatment modalities, including its use as a depigmenting therapy in generalized/universal vitiligo, is discussed. Screening for anti-nuclear antibodies and tailoring approaches for non-photo-adapters are also examined.
CONCLUSIONS: In conclusion, this review provides a comprehensive overview of phototherapy for vitiligo treatment. It underscores the evolving landscape of phototherapy and offers insights into optimizing therapeutic outcomes and addressing the challenges ahead. By integrating clinical evidence with molecular understanding, phototherapy emerges as a valuable therapeutic option for managing vitiligo, with potential for further advancements in the field.
OBJECTIVE: This narrative review aims to explore the clinical applications and molecular mechanisms of phototherapy in vitiligo.
CONCLUSIONS: The review evaluates existing literature on phototherapy for vitiligo, analyzing studies on hospital-based and home-based phototherapy, as well as outcomes related to stabilization and repigmentation. Narrowband ultra-violet B, that is, NBUVB remains the most commonly employed, studied and effective phototherapy modality for vitiligo. Special attention is given to assessing different types of lamps, dosimetry, published guidelines, and the utilization of targeted phototherapy modalities. Additionally, the integration of phototherapy with other treatment modalities, including its use as a depigmenting therapy in generalized/universal vitiligo, is discussed. Screening for anti-nuclear antibodies and tailoring approaches for non-photo-adapters are also examined.
CONCLUSIONS: In conclusion, this review provides a comprehensive overview of phototherapy for vitiligo treatment. It underscores the evolving landscape of phototherapy and offers insights into optimizing therapeutic outcomes and addressing the challenges ahead. By integrating clinical evidence with molecular understanding, phototherapy emerges as a valuable therapeutic option for managing vitiligo, with potential for further advancements in the field.
摘要：
背景：白癜风的特征是由于黑素细胞丢失而导致的色斑脱色素。光疗已成为白癜风的突出治疗选择，利用各种光模式来诱导疾病的稳定性和色素沉着。
目的：本综述旨在探讨光疗在白癜风中的临床应用及分子机制。
结论：本综述评估了现有的光疗治疗白癜风的文献，分析基于医院和家庭的光疗研究，以及与稳定和色素沉着相关的结果。窄带紫外线B,也就是说,NBUVB仍然是最常用的，白癜风研究和有效的光疗方式。特别注意评估不同类型的灯，剂量测定法,公布的指导方针,以及靶向光疗方式的利用。此外,光疗与其他治疗方式的整合，包括其作为广泛/普遍白癜风的脱色疗法，正在讨论。还检查了抗核抗体的筛选和非光衔接子的定制方法。
结论：结论：本综述对光疗治疗白癜风进行了全面综述。它强调了光疗不断发展的格局，并提供了优化治疗结果和应对未来挑战的见解。通过将临床证据与分子理解相结合，光疗作为管理白癜风的一种有价值的治疗选择，在该领域有进一步发展的潜力。
目的：本综述旨在探讨光疗在白癜风中的临床应用及分子机制。
结论：本综述评估了现有的光疗治疗白癜风的文献，分析基于医院和家庭的光疗研究，以及与稳定和色素沉着相关的结果。窄带紫外线B,也就是说,NBUVB仍然是最常用的，白癜风研究和有效的光疗方式。特别注意评估不同类型的灯，剂量测定法,公布的指导方针,以及靶向光疗方式的利用。此外,光疗与其他治疗方式的整合，包括其作为广泛/普遍白癜风的脱色疗法，正在讨论。还检查了抗核抗体的筛选和非光衔接子的定制方法。
结论：结论：本综述对光疗治疗白癜风进行了全面综述。它强调了光疗不断发展的格局，并提供了优化治疗结果和应对未来挑战的见解。通过将临床证据与分子理解相结合，光疗作为管理白癜风的一种有价值的治疗选择，在该领域有进一步发展的潜力。
