PDF(Pubmed)
Abstract：
BACKGROUND: Autoimmune hepatitis (AIH) is an organ specific autoimmune disease, which can manifest at any age of life. there is a high prevalence of extrahepatic autoimmune diseases in patients with AIH. Autoimmune thyroid diseases (ATDs) are the most frequent extrahepatic autoimmune disorders among patients with AIH. Aim of work is to detect the frequency of ATDs among Egyptian children with AIH.
METHODS: This research is a cross-sectional study conducted on 58 children with AIH aged ≤ 18 years. All patients were tested for free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG). Thyroid ultrasound (US) and thyroid scan were performed for patients with abnormal thyroid profile, borderline values, positive anti-TPO or anti-TG.
RESULTS: The mean ± standard deviation (SD) for the age of the patients was 11.3 ± 4.5 years. Out of 58 patients of AIH, 28 patients (48.3%) had associated other autoimmune diseases. Autoimmune thyroiditis was the most common associated autoimmune disease being present in 10 patients (17.2%). The thyroid status of AIT patients showed that 6 patients (60%) were euthyroid, 3 patients (30%) had subclinical hypothyroidism and only one patient (10%) was hyperthyroid.
CONCLUSIONS: Autoimmune hepatitis in Egyptian children is commonly associated with other autoimmune diseases. Autoimmune thyroiditis is the most common to be associated with AIH in pediatric patients. As it is not usually clinically manifesting, regular screening for AIT in children with AIH is mandatory.
METHODS: This research is a cross-sectional study conducted on 58 children with AIH aged ≤ 18 years. All patients were tested for free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG). Thyroid ultrasound (US) and thyroid scan were performed for patients with abnormal thyroid profile, borderline values, positive anti-TPO or anti-TG.
RESULTS: The mean ± standard deviation (SD) for the age of the patients was 11.3 ± 4.5 years. Out of 58 patients of AIH, 28 patients (48.3%) had associated other autoimmune diseases. Autoimmune thyroiditis was the most common associated autoimmune disease being present in 10 patients (17.2%). The thyroid status of AIT patients showed that 6 patients (60%) were euthyroid, 3 patients (30%) had subclinical hypothyroidism and only one patient (10%) was hyperthyroid.
CONCLUSIONS: Autoimmune hepatitis in Egyptian children is commonly associated with other autoimmune diseases. Autoimmune thyroiditis is the most common to be associated with AIH in pediatric patients. As it is not usually clinically manifesting, regular screening for AIT in children with AIH is mandatory.
摘要：
背景：自身免疫性肝炎（AIH）是一种器官特异性自身免疫性疾病，可以在生命的任何年龄表现出来。AIH患者的肝外自身免疫性疾病患病率较高.自身免疫性甲状腺疾病（ATDs）是AIH患者中最常见的肝外自身免疫性疾病。工作的目的是检测埃及AIH儿童中ATDs的频率。
方法：这项研究是对58名年龄≤18岁的AIH儿童进行的横断面研究。所有患者均接受游离三碘甲状腺原氨酸（FT3）检测，游离四碘甲状腺原氨酸（FT4），促甲状腺激素(TSH),抗甲状腺过氧化物酶（抗TPO）和抗甲状腺球蛋白（抗TG）。对甲状腺异常的患者进行甲状腺超声（US）和甲状腺扫描，边界值，阳性抗TPO或抗TG。
结果：患者年龄的平均值±标准差（SD）为11.3±4.5岁。在58例AIH患者中，28例(48.3%)患者有其他自身免疫性疾病。自身免疫性甲状腺炎是最常见的相关自身免疫性疾病，在10例患者中存在（17.2％）。AIT患者甲状腺状态显示6例(60%)甲状腺功能正常,3例（30％）患有亚临床甲状腺功能减退，只有1例（10％）患有甲状腺功能亢进。
结论：埃及儿童的自身免疫性肝炎通常与其他自身免疫性疾病有关。自身免疫性甲状腺炎是儿科患者中最常见的与AIH相关的甲状腺炎。因为它通常不是临床表现，AIH患儿必须定期进行AIT筛查.
方法：这项研究是对58名年龄≤18岁的AIH儿童进行的横断面研究。所有患者均接受游离三碘甲状腺原氨酸（FT3）检测，游离四碘甲状腺原氨酸（FT4），促甲状腺激素(TSH),抗甲状腺过氧化物酶（抗TPO）和抗甲状腺球蛋白（抗TG）。对甲状腺异常的患者进行甲状腺超声（US）和甲状腺扫描，边界值，阳性抗TPO或抗TG。
结果：患者年龄的平均值±标准差（SD）为11.3±4.5岁。在58例AIH患者中，28例(48.3%)患者有其他自身免疫性疾病。自身免疫性甲状腺炎是最常见的相关自身免疫性疾病，在10例患者中存在（17.2％）。AIT患者甲状腺状态显示6例(60%)甲状腺功能正常,3例（30％）患有亚临床甲状腺功能减退，只有1例（10％）患有甲状腺功能亢进。
结论：埃及儿童的自身免疫性肝炎通常与其他自身免疫性疾病有关。自身免疫性甲状腺炎是儿科患者中最常见的与AIH相关的甲状腺炎。因为它通常不是临床表现，AIH患儿必须定期进行AIT筛查.
