Abstract：
OBJECTIVE: Given the increased risk of fetal acidosis in singleton neonates born to pregnant people with an elevated BMI, our objective was to evaluate the association between pre-pregnancy/first-trimester BMI and fetal acidosis among term twin pregnancies.
METHODS: Retrospective study of pregnant people with twin gestation and their term infants admitted to our centre between 2014 and 2019. Using a generalized estimating equation, the association between maternal BMI and fetal acidosis was determined using odds ratios (ORs) with 95% CIs. A two-sided P < 0.05 was considered significant.
RESULTS: A total of 275 pregnant people and 550 infants were analyzed. The number (%) of pregnancies in each BMI class were 10 (4%) underweight, 155 (56%) normal weight, 66 (24%) overweight, 22 (8%) class I, 9 (3%) class II, and 13 (5%) class III. The prevalence of maternal diabetes and hypertension was highest in class III (31%) and class II (44%), respectively. Fetal acidosis was diagnosed in 35 (6%) infants. After adjusting for confounders (maternal age, diabetes, and hypertension), infants born to those with elevated BMI did not have increased odds of fetal acidosis compared to those born to underweight and normal weight group (OR 1.29; 95% CI 0.38-4.41 for class I, P = 0.67 and OR 2.80; 95% CI 0.62-12.62 for the combined classes II and III, P = 0.18).
CONCLUSIONS: Maternal BMI was not associated with fetal acidosis in term twin pregnancies. Further research is required to corroborate study findings due to small sample size.
METHODS: Retrospective study of pregnant people with twin gestation and their term infants admitted to our centre between 2014 and 2019. Using a generalized estimating equation, the association between maternal BMI and fetal acidosis was determined using odds ratios (ORs) with 95% CIs. A two-sided P < 0.05 was considered significant.
RESULTS: A total of 275 pregnant people and 550 infants were analyzed. The number (%) of pregnancies in each BMI class were 10 (4%) underweight, 155 (56%) normal weight, 66 (24%) overweight, 22 (8%) class I, 9 (3%) class II, and 13 (5%) class III. The prevalence of maternal diabetes and hypertension was highest in class III (31%) and class II (44%), respectively. Fetal acidosis was diagnosed in 35 (6%) infants. After adjusting for confounders (maternal age, diabetes, and hypertension), infants born to those with elevated BMI did not have increased odds of fetal acidosis compared to those born to underweight and normal weight group (OR 1.29; 95% CI 0.38-4.41 for class I, P = 0.67 and OR 2.80; 95% CI 0.62-12.62 for the combined classes II and III, P = 0.18).
CONCLUSIONS: Maternal BMI was not associated with fetal acidosis in term twin pregnancies. Further research is required to corroborate study findings due to small sample size.
摘要：
目的：鉴于体重指数（BMI）升高的孕妇所生的单胎新生儿中胎儿酸中毒的风险增加，我们的目的是评估足月双胎妊娠中孕前/孕早期BMI与胎儿酸中毒之间的关系.
方法：回顾性研究2014年至2019年我们中心收治的双胎妊娠孕妇及其足月婴儿。使用广义估计方程，使用比值比(OR)和95%置信区间(CI)确定母体BMI与胎儿酸中毒之间的关联.双侧P值<0.05被认为是显著的。
结果：共分析了275名孕妇和550名婴儿。每个BMI类别的怀孕人数（％）为10（4％）体重不足，155（56%）正常体重，66（24％）超重，22（8%）一级，9（3%）II类，和13（5％）III类。孕产妇糖尿病和高血压的患病率在III类(31%)和II类(44%)中最高,分别。35例（6％）婴儿被诊断为胎儿酸中毒。在调整了混杂因素后(产妇年龄，糖尿病,和高血压），与体重过轻和体重正常组的婴儿相比,BMI升高的婴儿的胎儿酸中毒几率没有增加[I类(P=0.67)的OR为1.29(95%CI0.38~4.41),II类和III类(P=0.18)的OR为2.80(95%CI0.62~12.62)].
结论：在足月双胎妊娠中，孕妇BMI与胎儿酸中毒无关。由于样本量小，需要进一步的研究来证实研究结果。
方法：回顾性研究2014年至2019年我们中心收治的双胎妊娠孕妇及其足月婴儿。使用广义估计方程，使用比值比(OR)和95%置信区间(CI)确定母体BMI与胎儿酸中毒之间的关联.双侧P值<0.05被认为是显著的。
结果：共分析了275名孕妇和550名婴儿。每个BMI类别的怀孕人数（％）为10（4％）体重不足，155（56%）正常体重，66（24％）超重，22（8%）一级，9（3%）II类，和13（5％）III类。孕产妇糖尿病和高血压的患病率在III类(31%)和II类(44%)中最高,分别。35例（6％）婴儿被诊断为胎儿酸中毒。在调整了混杂因素后(产妇年龄，糖尿病,和高血压），与体重过轻和体重正常组的婴儿相比,BMI升高的婴儿的胎儿酸中毒几率没有增加[I类(P=0.67)的OR为1.29(95%CI0.38~4.41),II类和III类(P=0.18)的OR为2.80(95%CI0.62~12.62)].
结论：在足月双胎妊娠中，孕妇BMI与胎儿酸中毒无关。由于样本量小，需要进一步的研究来证实研究结果。
