Abstract：
OBJECTIVE: QTc interval prolongation is a growing global issue which can cause torsades de pointes, a potentially fatal arrhythmia. We aimed to identify risk factors for prolonged QT interval in men and women.
METHODS: The Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study collected electrocardiogram interval data. QT was corrected for heart rate using the Bazett\'s formula. Ordinal logistic regression with crude (univariable) and adjusted (multivariate) association analyses in the form of odds ratio and corresponding 95% confidence interval (CI) were used to identify the factors associated with QTc prolongation.
RESULTS: A total of 8878 individuals including 5318 females and 3560 males, aged 35 to 65 years, were included in this cross-sectional study. Participants with QTc prolongation were more likely to be older and have hypercholesterolemia, hypertension (HTN), and Type 2 diabetes mellitus (T2DM), but to have lower levels of physical activity (P < 0.05). Age (OR = 1.68, 95%CI = 1.18-2.39), hypercholesterolemia (OR = 1.77, 95%CI = 1.24-2.51), HTN (OR = 1.36, 95%CI = 1.06-1.73), T2DM (OR = 1.59, 95%CI = 1.19-2.13), severe anxiety (OR = 1.80, 95%CI = 1.05-3.11) and mild depression (OR = 1.38, 95%CI = 1.01-1.88) were independent risk factors for prolonged QTc interval in men. For women, only HTN (OR = 1.29, 95%CI = 1.02-1.63) and T2DM (OR = 1.50, 95%CI = 1.14-1.97) were independent risk factors.
CONCLUSIONS: Older age, Hypercholesterolemia, HTN, T2DM, severe anxiety and mild depression in men, and HTN and T2DM in women were associated with high risk of prolonged QTc interval. Healthcare practitioners should be aware of the risk factors of QTc interval prolongation and should exercise caution in the management of certain patients.
METHODS: The Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study collected electrocardiogram interval data. QT was corrected for heart rate using the Bazett\'s formula. Ordinal logistic regression with crude (univariable) and adjusted (multivariate) association analyses in the form of odds ratio and corresponding 95% confidence interval (CI) were used to identify the factors associated with QTc prolongation.
RESULTS: A total of 8878 individuals including 5318 females and 3560 males, aged 35 to 65 years, were included in this cross-sectional study. Participants with QTc prolongation were more likely to be older and have hypercholesterolemia, hypertension (HTN), and Type 2 diabetes mellitus (T2DM), but to have lower levels of physical activity (P < 0.05). Age (OR = 1.68, 95%CI = 1.18-2.39), hypercholesterolemia (OR = 1.77, 95%CI = 1.24-2.51), HTN (OR = 1.36, 95%CI = 1.06-1.73), T2DM (OR = 1.59, 95%CI = 1.19-2.13), severe anxiety (OR = 1.80, 95%CI = 1.05-3.11) and mild depression (OR = 1.38, 95%CI = 1.01-1.88) were independent risk factors for prolonged QTc interval in men. For women, only HTN (OR = 1.29, 95%CI = 1.02-1.63) and T2DM (OR = 1.50, 95%CI = 1.14-1.97) were independent risk factors.
CONCLUSIONS: Older age, Hypercholesterolemia, HTN, T2DM, severe anxiety and mild depression in men, and HTN and T2DM in women were associated with high risk of prolonged QTc interval. Healthcare practitioners should be aware of the risk factors of QTc interval prolongation and should exercise caution in the management of certain patients.
摘要：
目的：QTc间期延长是一个日益严重的全球性问题，它可能会导致尖端扭转，可能致命的心律失常.我们旨在确定男性和女性QT间期延长的危险因素。
方法：马什哈德卒中和心脏动脉粥样硬化障碍（MASHAD）队列研究收集了心电图间期数据。使用Bazett公式校正QT心率。以比值比和相应的95％置信区间（CI）为形式的粗（单变量）和调整（多变量）关联分析的有序逻辑回归用于识别与QTc延长相关的因素。
结果:共8878人,其中女性5318人,男性3560人,35至65岁，纳入本横断面研究。QTc延长的参与者更有可能年龄较大，并且有高胆固醇血症，高血压（HTN），和2型糖尿病（T2DM），但体力活动水平较低(P<0.05)。年龄（OR=1.68，95CI=1.18-2.39），高胆固醇血症（OR=1.77，95CI=1.24-2.51），HTN（OR=1.36，95CI=1.06-1.73），T2DM（OR=1.59，95CI=1.19-2.13），重度焦虑(OR=1.80,95CI=1.05~3.11)和轻度抑郁(OR=1.38,95CI=1.01~1.88)是男性QTc间期延长的独立危险因素。对女人来说,仅HTN(OR=1.29,95CI=1.02~1.63)和T2DM(OR=1.50,95CI=1.14~1.97)为独立危险因素。
结论：年龄较大，高胆固醇血症,HTN,T2DM,男性的严重焦虑和轻度抑郁，女性的HTN和T2DM与QTc间期延长的高风险相关。医疗从业者应了解QTc间期延长的危险因素，并应谨慎管理某些患者。
方法：马什哈德卒中和心脏动脉粥样硬化障碍（MASHAD）队列研究收集了心电图间期数据。使用Bazett公式校正QT心率。以比值比和相应的95％置信区间（CI）为形式的粗（单变量）和调整（多变量）关联分析的有序逻辑回归用于识别与QTc延长相关的因素。
结果:共8878人,其中女性5318人,男性3560人,35至65岁，纳入本横断面研究。QTc延长的参与者更有可能年龄较大，并且有高胆固醇血症，高血压（HTN），和2型糖尿病（T2DM），但体力活动水平较低(P<0.05)。年龄（OR=1.68，95CI=1.18-2.39），高胆固醇血症（OR=1.77，95CI=1.24-2.51），HTN（OR=1.36，95CI=1.06-1.73），T2DM（OR=1.59，95CI=1.19-2.13），重度焦虑(OR=1.80,95CI=1.05~3.11)和轻度抑郁(OR=1.38,95CI=1.01~1.88)是男性QTc间期延长的独立危险因素。对女人来说,仅HTN(OR=1.29,95CI=1.02~1.63)和T2DM(OR=1.50,95CI=1.14~1.97)为独立危险因素。
结论：年龄较大，高胆固醇血症,HTN,T2DM,男性的严重焦虑和轻度抑郁，女性的HTN和T2DM与QTc间期延长的高风险相关。医疗从业者应了解QTc间期延长的危险因素，并应谨慎管理某些患者。
