Abstract：
UNASSIGNED: Hirsutism represents a significant concern for women with polycystic ovary syndrome (PCOS), with deleterious psychological effects warranting acknowledgment and a clear imperative to provide effective management. To our knowledge, this is the first review to exclusively examine the effectiveness of laser and light-based therapies in addressing hirsutism in women with PCOS.
UNASSIGNED: To synthesize the existing literature regarding the effectiveness of laser and light hair reduction therapies, either as stand-alone treatments or in combination with systemic agents, in treating hirsutism for women with PCOS.
UNASSIGNED: A systematic literature review was performed using MEDLINE, Embase, EMCARE, and CINAHL according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. Articles written in English, reporting on patients who met pre-established inclusion criteria were selected. Objective and subjectively measured outcomes relating to the effect of laser or light-based hair reduction therapies on hirsutism were abstracted. Heterogeneity among included studies precluded a meta-analysis, necessitating a narrative synthesis.
UNASSIGNED: Six studies reporting data on 423 individual patients with PCOS who underwent laser or light-based hair reduction therapies were included: 4 randomized clinical trials and 2 cohort studies. Alexandrite laser demonstrated significant improvements in hirsutism severity and psychological outcomes, particularly at high-fluence application. Alexandrite laser was also found to be more effective than intense pulsed light (IPL). The combination of diode laser with either metformin or combined oral contraceptive pill was superior to the application of diode laser alone, just as the addition of metformin to IPL demonstrated superior results to IPL treatment alone. Overall, most interventions were well tolerated. The overall certainty of evidence across all outcomes and comparisons was limited in part due to the observational nature of some studies.
UNASSIGNED: This systematic review highlights the potential of laser and light hair reduction therapies, both as stand-alone treatments and in combination with other pharmacological agents in PCOS. However, this review was limited by low certainty of the evidence, few studies evaluating effectiveness and safety in those with skin of color, and heterogeneity in outcome assessment. Future studies are needed to provide more robust evidence among diverse individuals with PCOS and hirsutism.
UNASSIGNED: To synthesize the existing literature regarding the effectiveness of laser and light hair reduction therapies, either as stand-alone treatments or in combination with systemic agents, in treating hirsutism for women with PCOS.
UNASSIGNED: A systematic literature review was performed using MEDLINE, Embase, EMCARE, and CINAHL according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. Articles written in English, reporting on patients who met pre-established inclusion criteria were selected. Objective and subjectively measured outcomes relating to the effect of laser or light-based hair reduction therapies on hirsutism were abstracted. Heterogeneity among included studies precluded a meta-analysis, necessitating a narrative synthesis.
UNASSIGNED: Six studies reporting data on 423 individual patients with PCOS who underwent laser or light-based hair reduction therapies were included: 4 randomized clinical trials and 2 cohort studies. Alexandrite laser demonstrated significant improvements in hirsutism severity and psychological outcomes, particularly at high-fluence application. Alexandrite laser was also found to be more effective than intense pulsed light (IPL). The combination of diode laser with either metformin or combined oral contraceptive pill was superior to the application of diode laser alone, just as the addition of metformin to IPL demonstrated superior results to IPL treatment alone. Overall, most interventions were well tolerated. The overall certainty of evidence across all outcomes and comparisons was limited in part due to the observational nature of some studies.
UNASSIGNED: This systematic review highlights the potential of laser and light hair reduction therapies, both as stand-alone treatments and in combination with other pharmacological agents in PCOS. However, this review was limited by low certainty of the evidence, few studies evaluating effectiveness and safety in those with skin of color, and heterogeneity in outcome assessment. Future studies are needed to provide more robust evidence among diverse individuals with PCOS and hirsutism.
摘要：
■多毛症是多囊卵巢综合征（PCOS）女性的重要问题，具有有害的心理影响，值得承认，并明确必须提供有效的管理。据我们所知,这是首次专门研究激光和光治疗在治疗PCOS女性多毛症中的有效性的综述.
■为了综合现有的关于激光和光减发疗法有效性的文献，作为独立治疗或与全身药物组合，治疗多毛症的妇女与PCOS。
■使用MEDLINE进行了系统的文献综述，Embase,EMCARE,根据系统审查和荟萃分析（PRISMA）报告指南的首选报告项目和CINAHL。用英语写的文章，我们选择了符合预设纳入标准的患者报告.提取了与激光或基于光的减毛疗法对多毛症的影响有关的客观和主观测量结果。纳入研究之间的异质性排除了荟萃分析，需要叙事综合。
■六项研究报告了423名PCOS患者接受激光或基于光的脱发治疗的数据：4项随机临床试验和2项队列研究。Alexandrite激光显着改善了多毛症的严重程度和心理结果，特别是在高通量应用中。还发现亚历山大石激光比强脉冲光（IPL）更有效。二极管激光与二甲双胍或联合口服避孕药的组合优于单独使用二极管激光，正如在IPL中添加二甲双胍显示优于单独IPL治疗的结果一样。总的来说,大多数干预措施耐受性良好.所有结果和比较的证据的总体确定性有限，部分原因是一些研究的观察性质。
■本系统综述强调了激光和轻度减发疗法的潜力，作为PCOS的独立治疗和与其他药物联合治疗。然而,这项审查受到证据确定性低的限制，很少有研究评估肤色皮肤的有效性和安全性，和结果评估中的异质性。未来的研究需要在PCOS和多毛症的不同个体中提供更有力的证据。
■为了综合现有的关于激光和光减发疗法有效性的文献，作为独立治疗或与全身药物组合，治疗多毛症的妇女与PCOS。
■使用MEDLINE进行了系统的文献综述，Embase,EMCARE,根据系统审查和荟萃分析（PRISMA）报告指南的首选报告项目和CINAHL。用英语写的文章，我们选择了符合预设纳入标准的患者报告.提取了与激光或基于光的减毛疗法对多毛症的影响有关的客观和主观测量结果。纳入研究之间的异质性排除了荟萃分析，需要叙事综合。
■六项研究报告了423名PCOS患者接受激光或基于光的脱发治疗的数据：4项随机临床试验和2项队列研究。Alexandrite激光显着改善了多毛症的严重程度和心理结果，特别是在高通量应用中。还发现亚历山大石激光比强脉冲光（IPL）更有效。二极管激光与二甲双胍或联合口服避孕药的组合优于单独使用二极管激光，正如在IPL中添加二甲双胍显示优于单独IPL治疗的结果一样。总的来说,大多数干预措施耐受性良好.所有结果和比较的证据的总体确定性有限，部分原因是一些研究的观察性质。
■本系统综述强调了激光和轻度减发疗法的潜力，作为PCOS的独立治疗和与其他药物联合治疗。然而,这项审查受到证据确定性低的限制，很少有研究评估肤色皮肤的有效性和安全性，和结果评估中的异质性。未来的研究需要在PCOS和多毛症的不同个体中提供更有力的证据。
