Abstract：
OBJECTIVE: The mainstay of treatment for nonmelanoma skin cancer (NMSC) on thin skin remains surgical, but procedures on older hands may be complicated by skin fragility and dermal atrophy. Used without cooling, 595 nm (nm) pulsed dye laser (PDL) has the capability of destroying NMSC through nonspecific thermal necrosis. The purpose of this study was to understand recurrence of NMSC on dorsal hands of older patients after one or two treatments using 595 nm PDL.
METHODS: A retrospective chart review identified 147 cases of NMSC located on the dorsal hands treated with 595 nm PDL. Cases of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) were included. All patients received one to two treatments with PDL. The primary outcome was the recurrence of carcinoma.
RESULTS: Among NMSC cases treated with PDL, recurrence occurred in 12 patients (8.2%). No cases of BCC recurred during the study period. Recurrence of SCC was 4.7% for SCC in situ and 10.4% recurrence for invasive SCC (p = 0.34). Among 71 patients treated once, recurrence occurred in 10 patients (14.1%), and among 76 cases treated twice, recurrence occurred in 2 patients (2.6%, p = 0.01).
CONCLUSIONS: Two treatments of PDL for NMSC on the dorsal hands of older patients was well tolerated, had low recurrence, and seemed more effective than one treatment.
METHODS: A retrospective chart review identified 147 cases of NMSC located on the dorsal hands treated with 595 nm PDL. Cases of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) were included. All patients received one to two treatments with PDL. The primary outcome was the recurrence of carcinoma.
RESULTS: Among NMSC cases treated with PDL, recurrence occurred in 12 patients (8.2%). No cases of BCC recurred during the study period. Recurrence of SCC was 4.7% for SCC in situ and 10.4% recurrence for invasive SCC (p = 0.34). Among 71 patients treated once, recurrence occurred in 10 patients (14.1%), and among 76 cases treated twice, recurrence occurred in 2 patients (2.6%, p = 0.01).
CONCLUSIONS: Two treatments of PDL for NMSC on the dorsal hands of older patients was well tolerated, had low recurrence, and seemed more effective than one treatment.
摘要：
目的：薄皮肤非黑色素瘤皮肤癌（NMSC）的主要治疗方法仍然是手术，但是，由于皮肤脆弱和皮肤萎缩，老年手的手术可能会变得复杂。无需冷却即可使用，595nm（nm）脉冲染料激光（PDL）具有通过非特异性热坏死破坏NMSC的能力。这项研究的目的是了解使用595nmPDL进行一次或两次治疗后，老年患者背侧NMSC的复发。
方法：回顾性分析发现147例NMSC位于背侧手，用595nmPDL治疗。包括基底细胞癌（BCC）和鳞状细胞癌（SCC）的病例。所有患者接受1至2次PDL治疗。主要结果是癌症的复发。
结果：在接受PDL治疗的NMSC病例中，12例患者复发(8.2%).研究期间无BCC病例复发。原位SCC复发率为4.7%，侵袭性SCC复发率为10.4%(p=0.34)。在接受过一次治疗的71例患者中，复发10例(14.1%),在76例接受两次治疗的病例中，2例患者复发(2.6%,p=0.01)。
结论：两种PDL治疗老年患者背手NMSC的耐受性良好，复发率低，似乎比一种治疗更有效。
方法：回顾性分析发现147例NMSC位于背侧手，用595nmPDL治疗。包括基底细胞癌（BCC）和鳞状细胞癌（SCC）的病例。所有患者接受1至2次PDL治疗。主要结果是癌症的复发。
结果：在接受PDL治疗的NMSC病例中，12例患者复发(8.2%).研究期间无BCC病例复发。原位SCC复发率为4.7%，侵袭性SCC复发率为10.4%(p=0.34)。在接受过一次治疗的71例患者中，复发10例(14.1%),在76例接受两次治疗的病例中，2例患者复发(2.6%,p=0.01)。
结论：两种PDL治疗老年患者背手NMSC的耐受性良好，复发率低，似乎比一种治疗更有效。
