Abstract：
OBJECTIVE: To study response to water drinking provocation in primary open angle glaucoma (POAG), ocular hypertensives and glaucoma suspects and establish the role of water drinking provocation test (WDPT) as a relevant supplementary tool in glaucoma management.
METHODS: 319 eyes of 161 patients were included in the study after retrospectively analyzing hospital records of patients who underwent WDPT. The patients were categorized into Group A (POAG on treatment), Group B (treatment-naïve POAG), Group C (Ocular hypertensives), Group D (glaucoma suspects). All patients were asked to drink 1 liter of water within 5 min and intraocular pressures (IOP) were recorded after 20 and 30 min of water intake. The baseline, peak and IOP fluctuation were analysed. A fluctuation of ≥ 5 mm Hg was considered positive response.
RESULTS: 19 eyes were categorized as Group A, 58 as Group B, 96 and 146 eyes as groups C and D respectively. Baseline IOP in different groups differed significantly. Mean peak IOP was higher in Groups B and C, followed by Groups A and D. Mean IOP fluctuation differed significantly across groups being maximum in Group A (7.0 ± 2.5) and minimum in Group D (4.8 ± 2.9). Positive WDPT response was seen in 89.5% eyes in Group A, 77.6% of those in Group B, 55.2% and 48.6% in Groups C and D respectively. The baseline IOP had a significant positive correlation with the peak IOP across all groups.
CONCLUSIONS: The WDPT is an inexpensive practical tool which serves as an invaluable aid in glaucoma management.
METHODS: 319 eyes of 161 patients were included in the study after retrospectively analyzing hospital records of patients who underwent WDPT. The patients were categorized into Group A (POAG on treatment), Group B (treatment-naïve POAG), Group C (Ocular hypertensives), Group D (glaucoma suspects). All patients were asked to drink 1 liter of water within 5 min and intraocular pressures (IOP) were recorded after 20 and 30 min of water intake. The baseline, peak and IOP fluctuation were analysed. A fluctuation of ≥ 5 mm Hg was considered positive response.
RESULTS: 19 eyes were categorized as Group A, 58 as Group B, 96 and 146 eyes as groups C and D respectively. Baseline IOP in different groups differed significantly. Mean peak IOP was higher in Groups B and C, followed by Groups A and D. Mean IOP fluctuation differed significantly across groups being maximum in Group A (7.0 ± 2.5) and minimum in Group D (4.8 ± 2.9). Positive WDPT response was seen in 89.5% eyes in Group A, 77.6% of those in Group B, 55.2% and 48.6% in Groups C and D respectively. The baseline IOP had a significant positive correlation with the peak IOP across all groups.
CONCLUSIONS: The WDPT is an inexpensive practical tool which serves as an invaluable aid in glaucoma management.
摘要：
目的：研究原发性开角型青光眼（POAG）对饮水激发的反应，怀疑高血压和青光眼，并确立了饮水激发试验（WDPT）作为青光眼管理中相关补充工具的作用。
方法：在回顾性分析接受WDPT患者的住院记录后，将161例患者的319只眼纳入研究。将患者分为A组（POAG治疗），B组（治疗初期POAG），C组（高血压），D组(怀疑青光眼)。要求所有患者在5分钟内喝1升水，并在20分钟和30分钟后记录眼压（IOP）。基线，分析峰值和IOP波动。≥5mmHg的波动被认为是阳性反应。
结果：19只眼被归类为A组，58为B组，96眼和146眼分别为C组和D组。不同组的基线眼压差异显著。B组和C组平均峰值IOP较高,A组和D组之间的平均眼压波动差异显著,A组最大(7.0±2.5),D组最小(4.8±2.9).A组89.5%的眼出现WDPT阳性反应,B组的77.6%，C组和D组分别为55.2%和48.6%。基线IOP与所有组的峰值IOP具有显著正相关。
结论：WDPT是一种廉价的实用工具，可作为青光眼管理的宝贵辅助手段。
方法：在回顾性分析接受WDPT患者的住院记录后，将161例患者的319只眼纳入研究。将患者分为A组（POAG治疗），B组（治疗初期POAG），C组（高血压），D组(怀疑青光眼)。要求所有患者在5分钟内喝1升水，并在20分钟和30分钟后记录眼压（IOP）。基线，分析峰值和IOP波动。≥5mmHg的波动被认为是阳性反应。
结果：19只眼被归类为A组，58为B组，96眼和146眼分别为C组和D组。不同组的基线眼压差异显著。B组和C组平均峰值IOP较高,A组和D组之间的平均眼压波动差异显著,A组最大(7.0±2.5),D组最小(4.8±2.9).A组89.5%的眼出现WDPT阳性反应,B组的77.6%，C组和D组分别为55.2%和48.6%。基线IOP与所有组的峰值IOP具有显著正相关。
结论：WDPT是一种廉价的实用工具，可作为青光眼管理的宝贵辅助手段。
