PDF(Pubmed)
Abstract：
Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning. Materials and methods: We included 60 participants in a double-blind, double-dummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. The standard group (SC), received doxycycline 100 mg twice and metronidazole 400 mg thrice orally plus placebo per vaginum for the same duration. The primary outcome was a clinical cure at post-intervention for visual analogue scale (VAS) for lower abdominal pain (LAP), and McCormack pain scale (McPS) for abdominal-pelvic tenderness. The secondary outcome included white blood cells (WBC) cells in the vaginal wet mount test, safety profile, and health-related quality of life assessed by SF-12. In addition, we used AdaBoost (AB), Naïve Bayes (NB), and Decision Tree (DT) classifiers in this study to analyze the experimental data. Results: The clinical cure for LAP and McPS in the SR vs SC group was 82.85% vs 81.48% and 83.85% vs 81.60% on Day 15 respectively. On Day 15, pus cells less than 10 in the SR vs SC group were 86.6% vs 76.6% respectively. No adverse effects were reported in both groups. The improvement in total SF-12 score on Day 30 for the SR vs SC group was 82.79% vs 80.04% respectively. In addition, our Naive Bayes classifier based on the leave-one-out model achieved the maximum accuracy (68.30%) for the classification of both groups of uPID. Conclusion: We concluded that the SR group is cost-effective, safer, and efficacious for curing uPID. Proposed alternative treatment (test drug) could be a substitute of standard drug used for Female genital tract infections.
摘要：
背景和目标：随着微生物对抗生素产生耐药性，自然,植物药或传统草药目前正怀着极大的好奇心和希望被研究。因此，探讨了无并发症盆腔炎（uPID）的补充和替代疗法的疗效。因此,这项研究确定了在标准对照的uPID中使用RosadamascenaMill油对西沙种子的治疗效果和安全性。此外,我们用机器学习分析了数据。材料和方法：我们包括60名双盲参与者，双假人,随机对照研究。芝麻和玫瑰油组（SR组）（n=30）的参与者在睡前接受14天疗程的黑芝麻粉（5gm）与玫瑰油（10mL）混合，每天一次口服安慰剂胶囊。标准组（SC），口服多西环素100mg两次，甲硝唑400mg三次，每次阴道服用安慰剂，持续时间相同。主要结果是下腹痛（LAP）的视觉模拟评分（VAS）干预后的临床治愈，和McCormack疼痛量表（McPS）用于腹部-骨盆压痛。次要结果包括阴道湿装试验中的白细胞（WBC）细胞，安全概况,和通过SF-12评估的健康相关生活质量。此外,我们使用AdaBoost（AB），朴素贝叶斯(NB)，和决策树(DT)分类器在这项研究中分析实验数据。结果：在第15天，SRvsSC组中LAP和McPS的临床治愈率分别为82.85％vs81.48％和83.85％vs81.60％。在第15天，SRvsSC组中小于10的脓液细胞分别为86.6％和76.6％。两组均无不良反应。在第30天,SR与SC组的总SF-12评分的改善分别为82.79%与80.04%。此外,我们基于留一模型的朴素贝叶斯分类器对两组uPID的分类均达到了最高准确率(68.30%).结论：我们的结论是SR组具有成本效益，更安全,并有效固化uPID。拟议的替代疗法（测试药物）可以替代用于女性生殖道感染的标准药物。
