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Abstract：
Sarcoidosis, a multifaceted systemic disorder characterized histologically by the presence of non-caseating granulomas, has a wide array of cutaneous manifestations. We describe a case of a 74-year-old woman with a complex medical history, who presented with asymptomatic hyperpigmented papules on her lower extremities. Histological examination of a punch biopsy specimen showed nodular and angiocentric patterns of granulomatous inflammation consistent with sarcoidosis, and chest radiography demonstrated bilateral hilar opacities, supporting the diagnosis. To our knowledge, this specific cutaneous presentation of sarcoidosis has not been described before, and it can easily be mistaken for other conditions. Therefore, this case underscores the importance of recognizing atypical cutaneous morphologies of sarcoidosis, particularly in patients with complex medical histories, to facilitate accurate diagnosis and timely intervention. We aim to increase awareness among clinicians regarding the diverse manifestations of sarcoidosis, thereby enhancing diagnostic acumen and patient care.
摘要：
结节病,一种多方面的系统性疾病，其组织学特征是存在非干酪性肉芽肿，有各种各样的皮肤表现。我们描述了一个有复杂病史的74岁女性的案例，她的下肢出现无症状的色素沉着丘疹。穿刺活检标本的组织学检查显示肉芽肿性炎症的结节和血管中心模式与结节病一致。胸部X线照相显示双侧肺门混浊，支持诊断。据我们所知,结节病的这种特殊的皮肤表现以前没有被描述过，很容易被误认为是其他条件。因此,该病例强调了识别结节病的非典型皮肤形态的重要性，特别是在有复杂病史的患者中，便于准确诊断和及时干预。我们的目标是提高临床医生对结节病的各种表现的认识，从而提高诊断敏锐度和病人护理。
