PDF(Pubmed)
Abstract：
UNASSIGNED: Androgenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between the gut microbiota and AGA.
UNASSIGNED: A two-sample MR investigation was utilized to delve into the intricate interplay between gut microbiota and AGA. Information regarding 211 gut microbial taxa was sourced from the MiBioGen consortium. The summary statistics of the genome-wide association studies (GWAS) for AGA were obtained from the FinnGen biobank, which included 195 cases and 201,019 controls. Various analytical approaches, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger, Weighted Mode, and Simple Mode were employed to evaluate the causal impact of gut microbiota on AGA. Sensitivity analyses were subsequently conducted to affirm the robustness of the findings.
UNASSIGNED: A two-sample MR investigation unveiled the genus Olsenella, genus Ruminococcaceae UCG-004, and genus Ruminococcaceae UCG-010 were identified as risk factors associated with AGA. In contrast, the family Acidaminococcaceae and genus Anaerofilum, along with the genus Ruminiclostridium 9, demonstrated a protective effect. The sensitivity analyses provided additional assurance that the findings of the current study were less susceptible to the influence of confounding variables and biases.
UNASSIGNED: The MR study has established a link between specific gut microbiota and AGA, offering evidence for the identification of more precisely targeted probiotics. This discovery has the potential to aid in the prevention, control, and reversal of AGA progression.
UNASSIGNED: A two-sample MR investigation was utilized to delve into the intricate interplay between gut microbiota and AGA. Information regarding 211 gut microbial taxa was sourced from the MiBioGen consortium. The summary statistics of the genome-wide association studies (GWAS) for AGA were obtained from the FinnGen biobank, which included 195 cases and 201,019 controls. Various analytical approaches, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger, Weighted Mode, and Simple Mode were employed to evaluate the causal impact of gut microbiota on AGA. Sensitivity analyses were subsequently conducted to affirm the robustness of the findings.
UNASSIGNED: A two-sample MR investigation unveiled the genus Olsenella, genus Ruminococcaceae UCG-004, and genus Ruminococcaceae UCG-010 were identified as risk factors associated with AGA. In contrast, the family Acidaminococcaceae and genus Anaerofilum, along with the genus Ruminiclostridium 9, demonstrated a protective effect. The sensitivity analyses provided additional assurance that the findings of the current study were less susceptible to the influence of confounding variables and biases.
UNASSIGNED: The MR study has established a link between specific gut microbiota and AGA, offering evidence for the identification of more precisely targeted probiotics. This discovery has the potential to aid in the prevention, control, and reversal of AGA progression.
摘要：
■雄激素性脱发（AGA）是最常见的雄激素相关脱发类型。先前的研究表明肠道微生物群与AGA之间存在关联。为了更深入地研究，我们进行了双样本孟德尔随机化(MR)分析,以调查肠道菌群与AGA之间的潜在因果关系.
■利用两个样本的MR调查来深入研究肠道微生物群和AGA之间的复杂相互作用。关于211个肠道微生物分类群的信息来自MiBioGen联盟。AGA的全基因组关联研究（GWAS）的汇总统计数据来自FinnGen生物样本库，其中包括195例病例和201,019例对照。各种分析方法，包括逆方差加权(IVW)，加权中位数，MR-Egger,加权模式,采用简单模式评估肠道菌群对AGA的因果影响。随后进行了敏感性分析，以确认研究结果的稳健性。
■一项由两个样本组成的MR调查揭示了Olsenella属，RuminococaceaeUCG-004和RuminococaceaeUCG-010被确定为与AGA相关的危险因素。相比之下,酸性球菌科和厌氧菌属，与Ruminiclostridium9属一起，表现出保护作用。敏感性分析提供了额外的保证，即当前研究的结果不太容易受到混杂变量和偏差的影响。
■MR研究已经建立了特定肠道微生物群和AGA之间的联系，为更精确靶向的益生菌的鉴定提供证据。这一发现有可能有助于预防，control,和AGA进展的逆转。
■利用两个样本的MR调查来深入研究肠道微生物群和AGA之间的复杂相互作用。关于211个肠道微生物分类群的信息来自MiBioGen联盟。AGA的全基因组关联研究（GWAS）的汇总统计数据来自FinnGen生物样本库，其中包括195例病例和201,019例对照。各种分析方法，包括逆方差加权(IVW)，加权中位数，MR-Egger,加权模式,采用简单模式评估肠道菌群对AGA的因果影响。随后进行了敏感性分析，以确认研究结果的稳健性。
■一项由两个样本组成的MR调查揭示了Olsenella属，RuminococaceaeUCG-004和RuminococaceaeUCG-010被确定为与AGA相关的危险因素。相比之下,酸性球菌科和厌氧菌属，与Ruminiclostridium9属一起，表现出保护作用。敏感性分析提供了额外的保证，即当前研究的结果不太容易受到混杂变量和偏差的影响。
■MR研究已经建立了特定肠道微生物群和AGA之间的联系，为更精确靶向的益生菌的鉴定提供证据。这一发现有可能有助于预防，control,和AGA进展的逆转。
