PDF(Pubmed)
Abstract：
Developmental delay is a public health problem in low- and middle-income countries. However, there is no summarized evidence in low- and middle-income countries on developmental delay, and primary studies on this issue show varied and inconclusive results. This systematic review and meta-analysis aimed to assess the pooled magnitude of confirmed developmental delay and its determinants among children in low- and middle-income countries.
We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to write this systematic review and meta-analysis. Primary studies were searched from PubMed, PsycINFO, Hinari, Science Direct, African Journal of Online, Web of Science, and Google Scholar databases. The Newcastle-Ottawa Scale, adapted for the cross-sectional studies, was used to assess the quality of the included studies. Heterogeneity and publication bias were assessed by the I2 and Eggers tests, respectively. Due to the high heterogeneity, the random effects model was used for analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to show the association between developmental delay and its determinants.
The pooled prevalence of confirmed developmental delay was 18.83, 95% CI (15.53-22.12). In the subgroup analysis, a high prevalence of developmental delay [26.69% (95% CI, 15.78-37.60)] was observed in studies performed in Africa. Maternal education [3.04; 95% CI (2.05, 4.52)] and low birth weight [3.61; 95% CI (1.72, 7.57)] were significant determinants of developmental delay.
The pooled prevalence of developmental delay in low- and middle-income countries was high as compared to that in high-income countries. Maternal education level and weight at birth were significantly associated with developmental delays. Therefore, strategies should be designed to decrease the rate of low birth weight and the number of illiterate mothers living in low- and middle-income countries.
PROSPERO, CRD42024513060.
We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to write this systematic review and meta-analysis. Primary studies were searched from PubMed, PsycINFO, Hinari, Science Direct, African Journal of Online, Web of Science, and Google Scholar databases. The Newcastle-Ottawa Scale, adapted for the cross-sectional studies, was used to assess the quality of the included studies. Heterogeneity and publication bias were assessed by the I2 and Eggers tests, respectively. Due to the high heterogeneity, the random effects model was used for analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to show the association between developmental delay and its determinants.
The pooled prevalence of confirmed developmental delay was 18.83, 95% CI (15.53-22.12). In the subgroup analysis, a high prevalence of developmental delay [26.69% (95% CI, 15.78-37.60)] was observed in studies performed in Africa. Maternal education [3.04; 95% CI (2.05, 4.52)] and low birth weight [3.61; 95% CI (1.72, 7.57)] were significant determinants of developmental delay.
The pooled prevalence of developmental delay in low- and middle-income countries was high as compared to that in high-income countries. Maternal education level and weight at birth were significantly associated with developmental delays. Therefore, strategies should be designed to decrease the rate of low birth weight and the number of illiterate mothers living in low- and middle-income countries.
PROSPERO, CRD42024513060.
摘要：
■发展延迟是低收入和中等收入国家的公共卫生问题。然而,在低收入和中等收入国家没有关于发展延迟的总结证据，关于这个问题的初步研究表明，结果各不相同，没有定论。本系统评价和荟萃分析旨在评估低收入和中等收入国家儿童中确认的发育迟缓及其决定因素的汇总程度。
■我们遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目撰写本系统评价和荟萃分析。主要研究从PubMed搜索，PsycINFO,Hinari,科学直接，非洲在线杂志，WebofScience,和谷歌学者数据库。纽卡斯尔-渥太华量表，适应横断面研究，用于评估纳入研究的质量。通过I2和Eggers检验评估异质性和发表偏倚，分别。由于高度的异质性，采用随机效应模型进行分析。具有95％置信区间（CI）的赔率（OR）用于显示发育延迟与其决定因素之间的关联。
■确认发育迟缓的合并患病率为18.83，95%CI（15.53-22.12）。在亚组分析中，在非洲进行的研究中观察到发育迟缓的高患病率[26.69%(95%CI,15.78-37.60)].母亲教育[3.04;95％CI（2.05，4.52）]和低出生体重[3.61;95％CI（1.72，7.57）]是发育迟缓的重要决定因素。
■与高收入国家相比，低收入和中等收入国家的发展延迟合并流行率高。母亲的教育水平和出生时的体重与发育迟缓显着相关。因此,低出生体重率和生活在低收入和中等收入国家的文盲母亲人数。
■PROSPERO，CRD42024513060。
■我们遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目撰写本系统评价和荟萃分析。主要研究从PubMed搜索，PsycINFO,Hinari,科学直接，非洲在线杂志，WebofScience,和谷歌学者数据库。纽卡斯尔-渥太华量表，适应横断面研究，用于评估纳入研究的质量。通过I2和Eggers检验评估异质性和发表偏倚，分别。由于高度的异质性，采用随机效应模型进行分析。具有95％置信区间（CI）的赔率（OR）用于显示发育延迟与其决定因素之间的关联。
■确认发育迟缓的合并患病率为18.83，95%CI（15.53-22.12）。在亚组分析中，在非洲进行的研究中观察到发育迟缓的高患病率[26.69%(95%CI,15.78-37.60)].母亲教育[3.04;95％CI（2.05，4.52）]和低出生体重[3.61;95％CI（1.72，7.57）]是发育迟缓的重要决定因素。
■与高收入国家相比，低收入和中等收入国家的发展延迟合并流行率高。母亲的教育水平和出生时的体重与发育迟缓显着相关。因此,低出生体重率和生活在低收入和中等收入国家的文盲母亲人数。
■PROSPERO，CRD42024513060。
