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Abstract：
UNASSIGNED: An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased activity of antioxidants, reduces insulin resistance and improves glucose transport. Maximal oxygen capacity (VO2max) is an objective measure of the body\'s aerobic capacity. To assess VO2max, oxygen uptake should be measured directly during the exercise test. The aim of the study was to evaluate the physical capacity in adults with DM1 and its relationship with the occurrence of partial clinical remission (pCR) during 2 years follow-up.
UNASSIGNED: The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO2max was assessed between 6th and 24th month of diabetes duration using an ergospirometer (COSMED K5 System), during an exercise test carried out on a cycloergometer (RAMP incremental exercise test).
UNASSIGNED: The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO2max level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate and multivariate regression confirmed a significant association between VO2max and presence of pCR [AOR 1.26 (1.05-1.52), P = .015]. Duration of remission was longer among group with higher VO2max results [15 (9-24) vs 9 (0-12) months, P = .043]. The positive relationship was observed between diabetes duration and VO2max (rs = 0.484, P = .005). Multivariate linear regression confirms a significant association between remission duration and VO2max (ml/min/kg) (β = 0.595, P = .002).
UNASSIGNED: The higher VO2max, the better chance of partial clinical remission at 2 years of DM1 and longer duration of remission.
Better cardiorespiratory fitness increases the chance of partial clinical remission and prolongs remission duration in people with newly diagnosed type 1 diabetes. Introduction An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased activity of antioxidants, reduces insulin resistance and improves glucose transport. Maximal oxygen capacity (VO2max) is an objective measure of the body’s aerobic capacity. To assess VO2max, oxygen uptake should be measured directly during the exercise test. The aim of the study was to evaluate the physical capacity in adults with DM1 and its relationship with the occurrence of partial clinical remission (pCR) during 2 years follow-up. Methods The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO2max was assessed between 6th and 24th month of diabetes duration using an ergospirometer (COSMED K5 System), during an exercise test carried out on a cycloergometer (RAMP incremental exercise test). Results The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO2max level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate and multivariate regression confirmed a significant association between VO2max and presence of pCR [AOR 1.26 (1.05-1.52), P = .015]. Duration of remission was longer among group with higher VO2max results [15 (9-24) vs 9 (0-12) months, P = .043]. The positive relationship was observed between diabetes duration and VO2max (rs = 0.484, P = .005). Multivariate linear regression confirms a significant association between remission duration and VO2max (ml/min/kg) (β = 0.595, P = .002). Conclusions The higher VO2max, the better chance of partial clinical remission at 2 years of DM1 and longer duration of remission.
UNASSIGNED: The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO2max was assessed between 6th and 24th month of diabetes duration using an ergospirometer (COSMED K5 System), during an exercise test carried out on a cycloergometer (RAMP incremental exercise test).
UNASSIGNED: The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO2max level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate and multivariate regression confirmed a significant association between VO2max and presence of pCR [AOR 1.26 (1.05-1.52), P = .015]. Duration of remission was longer among group with higher VO2max results [15 (9-24) vs 9 (0-12) months, P = .043]. The positive relationship was observed between diabetes duration and VO2max (rs = 0.484, P = .005). Multivariate linear regression confirms a significant association between remission duration and VO2max (ml/min/kg) (β = 0.595, P = .002).
UNASSIGNED: The higher VO2max, the better chance of partial clinical remission at 2 years of DM1 and longer duration of remission.
Better cardiorespiratory fitness increases the chance of partial clinical remission and prolongs remission duration in people with newly diagnosed type 1 diabetes. Introduction An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased activity of antioxidants, reduces insulin resistance and improves glucose transport. Maximal oxygen capacity (VO2max) is an objective measure of the body’s aerobic capacity. To assess VO2max, oxygen uptake should be measured directly during the exercise test. The aim of the study was to evaluate the physical capacity in adults with DM1 and its relationship with the occurrence of partial clinical remission (pCR) during 2 years follow-up. Methods The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO2max was assessed between 6th and 24th month of diabetes duration using an ergospirometer (COSMED K5 System), during an exercise test carried out on a cycloergometer (RAMP incremental exercise test). Results The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO2max level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate and multivariate regression confirmed a significant association between VO2max and presence of pCR [AOR 1.26 (1.05-1.52), P = .015]. Duration of remission was longer among group with higher VO2max results [15 (9-24) vs 9 (0-12) months, P = .043]. The positive relationship was observed between diabetes duration and VO2max (rs = 0.484, P = .005). Multivariate linear regression confirms a significant association between remission duration and VO2max (ml/min/kg) (β = 0.595, P = .002). Conclusions The higher VO2max, the better chance of partial clinical remission at 2 years of DM1 and longer duration of remission.
摘要：
■影响1型糖尿病（DM1）病程的基本过程是临床缓解的外观和持续时间。促进缓解发生的最重要因素之一是身体活动，由于抗氧化剂的活性增加，降低胰岛素抵抗并改善葡萄糖转运。最大氧容量(VO2max)是衡量人体有氧能力的客观指标。为了评估VO2max，应在运动测试中直接测量摄氧量。该研究的目的是评估DM1成人的身体能力及其与2年随访期间部分临床缓解（pCR）发生的关系。
通过以下数学公式评估pCR:A1c(%)+[4×胰岛素剂量(U/kg/d)]。结果多少9表示pCR。VO2max在糖尿病持续时间的第6个月至第24个月之间使用人体螺旋计（COSMEDK5系统）进行评估，在循环测力计上进行的运动测试（RAMP增量运动测试）。
■研究组由32名DM1成人组成。具有pCR的人被证明具有更高的VO2max水平[36.0（33.0-41.5）对30.9（26.5-34.4）ml/min/kg，P=.009。单变量和多变量回归证实了VO2max和pCR存在之间的显著关联[AOR1.26(1.05-1.52),P=.015]。VO2max结果较高的组的缓解持续时间较长[15（9-24）比9（0-12）个月，P=.043]。糖尿病病程与VO2max呈正相关(rs=0.484,P=0.005)。多元线性回归证实缓解时间与VO2max(ml/min/kg)之间存在显著关联(β=0.595,P=0.002)。
■VO2max越高，DM1治疗2年时部分临床缓解的机会更大，缓解持续时间更长。
在新诊断的1型糖尿病患者中，更好的心肺适应性增加了部分临床缓解的机会，并延长了缓解时间。介绍影响1型糖尿病（DM1）病程的基本过程是临床缓解的外观和持续时间。促进缓解发生的最重要因素之一是身体活动，由于抗氧化剂的活性增加，降低胰岛素抵抗并改善葡萄糖转运。最大氧容量（VO2max）是人体有氧能力的客观量度。为了评估VO2max，应在运动测试中直接测量摄氧量。该研究的目的是评估DM1成人的身体能力及其与2年随访期间部分临床缓解（pCR）发生的关系。方法通过以下数学公式评估pCR：A1c（％）[4×胰岛素剂量（U/kg/d）]。结果多少9表示pCR。VO2max在糖尿病持续时间的第6个月至第24个月之间使用人体螺旋计（COSMEDK5系统）进行评估，在循环测力计上进行的运动测试（RAMP增量运动测试）。结果研究组由32例DM1成人组成。具有pCR的人被证明具有更高的VO2max水平[36.0（33.0-41.5）对30.9（26.5-34.4）ml/min/kg，P=.009。单变量和多变量回归证实了VO2max和pCR存在之间的显著关联[AOR1.26(1.05-1.52),P=.015]。VO2max结果较高的组的缓解持续时间较长[15（9-24）比9（0-12）个月，P=.043]。糖尿病病程与VO2max呈正相关(rs=0.484,P=0.005)。多元线性回归证实缓解时间与VO2max(ml/min/kg)之间存在显著关联(β=0.595,P=0.002)。结论VO2max越高,DM1治疗2年时部分临床缓解的机会更大，缓解持续时间更长。
通过以下数学公式评估pCR:A1c(%)+[4×胰岛素剂量(U/kg/d)]。结果多少9表示pCR。VO2max在糖尿病持续时间的第6个月至第24个月之间使用人体螺旋计（COSMEDK5系统）进行评估，在循环测力计上进行的运动测试（RAMP增量运动测试）。
■研究组由32名DM1成人组成。具有pCR的人被证明具有更高的VO2max水平[36.0（33.0-41.5）对30.9（26.5-34.4）ml/min/kg，P=.009。单变量和多变量回归证实了VO2max和pCR存在之间的显著关联[AOR1.26(1.05-1.52),P=.015]。VO2max结果较高的组的缓解持续时间较长[15（9-24）比9（0-12）个月，P=.043]。糖尿病病程与VO2max呈正相关(rs=0.484,P=0.005)。多元线性回归证实缓解时间与VO2max(ml/min/kg)之间存在显著关联(β=0.595,P=0.002)。
■VO2max越高，DM1治疗2年时部分临床缓解的机会更大，缓解持续时间更长。
在新诊断的1型糖尿病患者中，更好的心肺适应性增加了部分临床缓解的机会，并延长了缓解时间。介绍影响1型糖尿病（DM1）病程的基本过程是临床缓解的外观和持续时间。促进缓解发生的最重要因素之一是身体活动，由于抗氧化剂的活性增加，降低胰岛素抵抗并改善葡萄糖转运。最大氧容量（VO2max）是人体有氧能力的客观量度。为了评估VO2max，应在运动测试中直接测量摄氧量。该研究的目的是评估DM1成人的身体能力及其与2年随访期间部分临床缓解（pCR）发生的关系。方法通过以下数学公式评估pCR：A1c（％）[4×胰岛素剂量（U/kg/d）]。结果多少9表示pCR。VO2max在糖尿病持续时间的第6个月至第24个月之间使用人体螺旋计（COSMEDK5系统）进行评估，在循环测力计上进行的运动测试（RAMP增量运动测试）。结果研究组由32例DM1成人组成。具有pCR的人被证明具有更高的VO2max水平[36.0（33.0-41.5）对30.9（26.5-34.4）ml/min/kg，P=.009。单变量和多变量回归证实了VO2max和pCR存在之间的显著关联[AOR1.26(1.05-1.52),P=.015]。VO2max结果较高的组的缓解持续时间较长[15（9-24）比9（0-12）个月，P=.043]。糖尿病病程与VO2max呈正相关(rs=0.484,P=0.005)。多元线性回归证实缓解时间与VO2max(ml/min/kg)之间存在显著关联(β=0.595,P=0.002)。结论VO2max越高,DM1治疗2年时部分临床缓解的机会更大，缓解持续时间更长。
