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Abstract：
UNASSIGNED: Although mutations in telomerase reverse transcriptase (TERT) promoter (TERTp) are the most common alterations in glioblastoma (GBM), predicting TERTp mutation status by preoperative imaging is difficult. We determined whether tumour-surrounding hyperintense lesions on fluid-attenuated inversion recovery (FLAIR) were superior to those of contrast-enhanced lesions (CELs) in assessing TERTp mutation status using magnetic resonance imaging (MRI).
UNASSIGNED: This retrospective study included 114 consecutive patients with primary isocitrate dehydrogenase (IDH)-wild-type GBM. The apparent diffusion coefficient (ADC) and volume of CELs and FLAIR hyperintense lesions (FHLs) were determined, and the correlation between MRI features and TERTp mutation status was analyzed. In a subset of cases, FHLs were histopathologically analyzed to determine the correlation between tumor cell density and ADC.
UNASSIGNED: TERTp mutations were present in 77 (67.5%) patients. The minimum ADC of FHLs was significantly lower in the TERTp-mutant group than in the TERTp-wild-type group (mean, 958.9 × 10-3 and 1092.1 × 10-3 mm2/s, respectively, P < 0.01). However, other MRI features, such as CEL and FHL volumes, minimum ADC of CELs, and FHL/CEL ratio, were not significantly different between the two groups. Histopathologic analysis indicated high tumor cell density in FHLs with low ADC.
UNASSIGNED: The ADC of FHLs was significantly lower in IDH-wild-type GBM with TERTp mutations, suggesting that determining the ADC of FHLs on preoperative MRI might be helpful in predicting TERTp mutation status and surgical planning.
UNASSIGNED: This retrospective study included 114 consecutive patients with primary isocitrate dehydrogenase (IDH)-wild-type GBM. The apparent diffusion coefficient (ADC) and volume of CELs and FLAIR hyperintense lesions (FHLs) were determined, and the correlation between MRI features and TERTp mutation status was analyzed. In a subset of cases, FHLs were histopathologically analyzed to determine the correlation between tumor cell density and ADC.
UNASSIGNED: TERTp mutations were present in 77 (67.5%) patients. The minimum ADC of FHLs was significantly lower in the TERTp-mutant group than in the TERTp-wild-type group (mean, 958.9 × 10-3 and 1092.1 × 10-3 mm2/s, respectively, P < 0.01). However, other MRI features, such as CEL and FHL volumes, minimum ADC of CELs, and FHL/CEL ratio, were not significantly different between the two groups. Histopathologic analysis indicated high tumor cell density in FHLs with low ADC.
UNASSIGNED: The ADC of FHLs was significantly lower in IDH-wild-type GBM with TERTp mutations, suggesting that determining the ADC of FHLs on preoperative MRI might be helpful in predicting TERTp mutation status and surgical planning.
摘要：
■尽管端粒酶逆转录酶（TERT）启动子（TERTp）的突变是胶质母细胞瘤（GBM）中最常见的改变，通过术前影像学预测TERTp突变状态是困难的。我们确定了在使用磁共振成像（MRI）评估TERTp突变状态时，在液体衰减倒置恢复（FLAIR）上的肿瘤周围高强度病变是否优于对比增强病变（CEL）。
■这项回顾性研究包括114例原发性异柠檬酸脱氢酶（IDH）野生型GBM的连续患者。测定CELs和FLAIR高强度病变(FHLs)的表观扩散系数(ADC)和体积,并分析MRI特征与TERTp突变状态的相关性。在一个子案例中，对FHL进行组织病理学分析以确定肿瘤细胞密度与ADC之间的相关性。
■TERTp突变存在于77例（67.5%）患者中。TERTp突变体组的FHLs的最小ADC值显着低于TERTp野生型组（平均值，958.9×10-3和1092.1×10-3mm2/s,分别,P<0.01)。然而,其他MRI特征，如CEL和FHL卷，CELs的最小ADC，和FHL/CEL比率，两组之间无显著差异。组织病理学分析显示FHL中肿瘤细胞密度高，ADC值低。
■在具有TERTp突变的IDH野生型GBM中，FHLs的ADC值显着降低，提示在术前MRI上确定FHLs的ADC可能有助于预测TERTp突变状态和手术计划。
■这项回顾性研究包括114例原发性异柠檬酸脱氢酶（IDH）野生型GBM的连续患者。测定CELs和FLAIR高强度病变(FHLs)的表观扩散系数(ADC)和体积,并分析MRI特征与TERTp突变状态的相关性。在一个子案例中，对FHL进行组织病理学分析以确定肿瘤细胞密度与ADC之间的相关性。
■TERTp突变存在于77例（67.5%）患者中。TERTp突变体组的FHLs的最小ADC值显着低于TERTp野生型组（平均值，958.9×10-3和1092.1×10-3mm2/s,分别,P<0.01)。然而,其他MRI特征，如CEL和FHL卷，CELs的最小ADC，和FHL/CEL比率，两组之间无显著差异。组织病理学分析显示FHL中肿瘤细胞密度高，ADC值低。
■在具有TERTp突变的IDH野生型GBM中，FHLs的ADC值显着降低，提示在术前MRI上确定FHLs的ADC可能有助于预测TERTp突变状态和手术计划。
