PDF(Pubmed)
Abstract：
Aplastic anaemia (AA) is a rare and life-threatening haematologic disorder characterised by pancytopenia and bone marrow failure. Its occurrence during pregnancy is exceedingly rare, posing significant risks and management challenges for both the mother and the foetus. We present here the case of a 23-year-old female, six months pregnant, diagnosed with severe aplastic anaemia (AA), aiming to highlight the diagnostic challenges and management considerations of AA in pregnancy. Our case underscores the critical nature of considering aplastic anaemia in differential diagnosis for pregnant patients presenting with unexplained pancytopenia. Based on that, we performed a comprehensive literature review of the past 20 years of papers published in the English language identified through searches in PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), Embase and the Cochrane Library, to provide an in-depth analysis of the current understanding of AA in pregnancy. We emphasise the necessity for cautious yet thorough investigation in such cases to avoid complications in both maternal and foetal health, focusing attention on the need for further research into safe and effective treatment protocols for managing AA in pregnancy, given the complexities introduced by the condition and its treatment on pregnancy outcomes.
摘要：
再生障碍性贫血（AA）是一种罕见且危及生命的血液系统疾病，其特征是全血细胞减少症和骨髓衰竭。它在怀孕期间的发生非常罕见，对母亲和胎儿构成重大风险和管理挑战。我们在这里介绍一个23岁女性的案例，怀孕六个月,诊断为严重再生障碍性贫血（AA），旨在强调妊娠AA的诊断挑战和管理注意事项。我们的病例强调了在对患有无法解释的全血细胞减少症的孕妇进行鉴别诊断时考虑再生障碍性贫血的重要性。基于此,我们对过去20年通过PubMed搜索确定的英语发表的论文进行了全面的文献综述，医学文献在线分析和检索系统（MEDLINE），Embase和Cochrane图书馆,深入分析当前对妊娠AA的认识。我们强调，在这种情况下，有必要进行谨慎而彻底的调查，以避免孕产妇和胎儿健康的并发症，重点关注需要进一步研究安全有效的妊娠AA治疗方案，考虑到病情及其对妊娠结局的治疗带来的复杂性。
