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Abstract：
BACKGROUND: The results of the use of del-Nido(DN) solution using a different method or crystalloid blood cardioplegia in coronary bypass patients were compared. We aimed to investigate the effects on intraoperative and postoperative arrhythmias, arrhythmia durations and early results.
METHODS: The study included 175 patients using crystalloid blood cardioplegia (Group 1) and 150 patients using DN solution(Group 2). In the DN group, 75% of the calculated plegia dose was given first. the remaining part was applied by giving from grafts. Intraoperative/postoperative data were compared.
RESULTS: There was no significant difference between the groups in terms of demographic characteristics. Preop troponin level was similar.(p = 0.190) However, there was a statistical difference between the postoperative 6th hour.(p = 0.001) There was no difference in troponin values at the postoperative 24th hour. (p = 0.631) Spontaneous rhythm occurred at the cardiopulmonary by pass (CPB) weaning stage in most of the patients in Group 2 (95.3%). Although the need for temporary pacing was less in Group 2, it was not significant.(p = 0.282) No patient required permanent pacing. CPB duration, cross clamp times and intraoperative glucose levels, intensive care follow-up times and hospitalization times were found to be shorter in Group 2. Although the postoperative atrial fibrillation frequency was similar (p = 0.261), the time to return to sinus was lower in Group 2.(p = 0.001).
CONCLUSIONS: The use of DN cardioplegia solution provides significant positive contributions to avoid arrhythmias compared to crystalloid blood cardioplegia. DN solution applied with this method may contribute to reducing the anxieties associated with its use in isolated coronary artery bypass surgery.
METHODS: The study included 175 patients using crystalloid blood cardioplegia (Group 1) and 150 patients using DN solution(Group 2). In the DN group, 75% of the calculated plegia dose was given first. the remaining part was applied by giving from grafts. Intraoperative/postoperative data were compared.
RESULTS: There was no significant difference between the groups in terms of demographic characteristics. Preop troponin level was similar.(p = 0.190) However, there was a statistical difference between the postoperative 6th hour.(p = 0.001) There was no difference in troponin values at the postoperative 24th hour. (p = 0.631) Spontaneous rhythm occurred at the cardiopulmonary by pass (CPB) weaning stage in most of the patients in Group 2 (95.3%). Although the need for temporary pacing was less in Group 2, it was not significant.(p = 0.282) No patient required permanent pacing. CPB duration, cross clamp times and intraoperative glucose levels, intensive care follow-up times and hospitalization times were found to be shorter in Group 2. Although the postoperative atrial fibrillation frequency was similar (p = 0.261), the time to return to sinus was lower in Group 2.(p = 0.001).
CONCLUSIONS: The use of DN cardioplegia solution provides significant positive contributions to avoid arrhythmias compared to crystalloid blood cardioplegia. DN solution applied with this method may contribute to reducing the anxieties associated with its use in isolated coronary artery bypass surgery.
摘要：
背景：比较了在冠状动脉搭桥患者中使用不同方法或晶体血液心脏停搏液的del-Nido（DN）溶液的结果。我们旨在探讨对术中和术后心律失常的影响，心律失常持续时间和早期结果。
方法：该研究包括175名使用晶体血液心脏停搏液的患者（第1组）和150名使用DN溶液的患者（第2组）。在DN组中，首先给予计算出的麻痹剂剂量的75%。剩余部分是通过从移植物给予。比较术中/术后数据。
结果：两组之间在人口统计学特征方面没有显着差异。术前肌钙蛋白水平相似。（p=0.190）然而，术后6小时有统计学差异。（p=0.001）术后24小时肌钙蛋白值无差异。（p=0.631）在第2组的大多数患者（95.3％）中，自发性心律发生在心肺旁路（CPB）断奶阶段。虽然在第2组中临时起搏的需要较少,但并不显著。(p=0.282)没有患者需要永久起搏。CPB持续时间,交叉钳夹时间和术中葡萄糖水平，第2组的重症监护随访时间和住院时间较短.尽管术后房颤频率相似（p=0.261），第2组患者恢复窦道的时间较少.（p=0.001）。
结论：与晶体血液心脏停搏液相比，使用DN心脏停搏液对避免心律失常具有显著的积极作用。与这种方法一起使用的DN溶液可能有助于减少与其在孤立的冠状动脉搭桥手术中使用相关的焦虑。
方法：该研究包括175名使用晶体血液心脏停搏液的患者（第1组）和150名使用DN溶液的患者（第2组）。在DN组中，首先给予计算出的麻痹剂剂量的75%。剩余部分是通过从移植物给予。比较术中/术后数据。
结果：两组之间在人口统计学特征方面没有显着差异。术前肌钙蛋白水平相似。（p=0.190）然而，术后6小时有统计学差异。（p=0.001）术后24小时肌钙蛋白值无差异。（p=0.631）在第2组的大多数患者（95.3％）中，自发性心律发生在心肺旁路（CPB）断奶阶段。虽然在第2组中临时起搏的需要较少,但并不显著。(p=0.282)没有患者需要永久起搏。CPB持续时间,交叉钳夹时间和术中葡萄糖水平，第2组的重症监护随访时间和住院时间较短.尽管术后房颤频率相似（p=0.261），第2组患者恢复窦道的时间较少.（p=0.001）。
结论：与晶体血液心脏停搏液相比，使用DN心脏停搏液对避免心律失常具有显著的积极作用。与这种方法一起使用的DN溶液可能有助于减少与其在孤立的冠状动脉搭桥手术中使用相关的焦虑。
