PDF(Pubmed)
Abstract：
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response, and cellular senescence. Current evidence suggests that PTEN is critical for stem cell maintenance, self-renewal, migration, lineage commitment, and differentiation. Based on the latest available evidence, we provide a comprehensive overview of the mechanisms by which PTEN regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer\'s disease and Parkinson\'s disease. This review aims to elucidate the therapeutic impacts and mechanisms of PTEN in relation to neurogenesis or the stem cell niche across a range of neurological disorders, offering a foundation for innovative therapeutic approaches aimed at tissue repair and regeneration in neurological disorders. This review unravels novel therapeutic strategies for tissue restoration and regeneration in neurological disorders based on the regulatory mechanisms of PTEN on neurogenesis and the stem cell niche.
摘要：
10号染色体（PTEN）上缺失的磷酸酶和张力蛋白同源物代表被鉴定为具有磷酸酶活性的初始肿瘤抑制基因，控制各种细胞过程，包括细胞周期调节，迁移,代谢途径，自噬,氧化应激反应，和细胞衰老。目前的证据表明，PTEN对干细胞的维持至关重要，自我更新,迁移,血统承诺，和差异化。根据现有的最新证据,我们全面概述了PTEN调节不同干细胞群活性和影响神经系统疾病的机制，包括自闭症，中风,脊髓损伤,创伤性脑损伤,阿尔茨海默病和帕金森病。这篇综述旨在阐明PTEN在一系列神经系统疾病中与神经发生或干细胞生态位相关的治疗影响和机制。为针对神经系统疾病的组织修复和再生的创新治疗方法奠定了基础。这篇综述基于PTEN对神经发生和干细胞生态位的调节机制，揭示了神经系统疾病中组织恢复和再生的新治疗策略。
