PDF(Pubmed)
Abstract：
Extramedullary relapse in patients with multiple myeloma (MM) is often associated with loss of biochemical response and the appearance of measurable residual disease in the bone marrow. Fever is an unusual presenting manifestation of MM. Treatment of extramedullary relapse in patients progressing on proteasome inhibitors, anti-CD38 monoclonal antibodies and immunomodulatory drugs is challenging, as access to chimeric antigen receptor T-cells and bispecific antibodies is limited. We report a case of relapsed MM who presented with fever and hepatic space-occupying lesion mimicking hepatocellular carcinoma. In this case report, we also present our experience of using a novel combination regimen comprising Dara-Pom-Benda-Dexa (daratumumab, pomalidomide, dexamethasone and bendamustine) for relapsed MM.
摘要：
多发性骨髓瘤（MM）患者的髓外复发通常与生化反应丧失和骨髓中可测量的残留疾病的出现有关。发烧是MM的不寻常表现。蛋白酶体抑制剂进展的患者髓外复发的治疗，抗CD38单克隆抗体和免疫调节药物具有挑战性，因为获得嵌合抗原受体T细胞和双特异性抗体的途径有限。我们报告了一例复发性MM，表现为发烧和模仿肝细胞癌的肝占位性病变。在这个案例报告中,我们还介绍了我们使用包含Dara-Pom-Benda-Dexa（daratumumab，泊马度胺,地塞米松和苯达莫司汀）用于复发MM。
