Abstract：
MicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend on the type of cell it is acting on and the specific target genes involved, resulting in different mechanisms of disease. Although, the exact part of miR-155 in cardiovascular illnesses is yet not fully comprehended, as some studies have shown it to promote the development of atherosclerosis while others have shown it to prevent it. As a result, to comprehend the underlying processes of miR-155 in cardiovascular disorders, further thorough study is required. It has been discovered that exosomes that could be absorbed by adjacent or distant cells, control post-transcriptional regulation of gene expression by focusing on mRNA. Exosomal miRNAs have been found to have a range of functions, including participating in inflammatory reactions, cell movement, growth, death, autophagy, as well as epithelial-mesenchymal transition. An increasing amount of research indicates that exosomal miRNAs are important for cardiovascular health and have a major role in the development of a number of cardiovascular disorders, including pulmonary hypertension, atherosclerosis, acute coronary syndrome, heart failure, and myocardial ischemia-reperfusion injury. Herein the role of miR-155 and its exosomal form in heart diseases are summarized.
摘要：
microRNAs（miRs，miRNA）已知在各种人类疾病中起作用，比如与心脏有关的。一种特定的miRNA，miR-155，已被广泛研究，并已被发现参与造血谱系分化，豁免权,病毒感染,炎症,以及血管重塑。这些过程都与心血管疾病有关，包括心力衰竭,糖尿病性心脏病,冠状动脉疾病,和腹主动脉瘤.miR-155的影响取决于它所作用的细胞类型和所涉及的特定靶基因。导致不同的疾病机制。虽然,miR-155在心血管疾病中的确切部分尚未完全理解，因为一些研究表明它可以促进动脉粥样硬化的发展，而另一些研究表明它可以预防动脉粥样硬化。因此,了解miR-155在心血管疾病中的潜在过程，需要进一步深入研究。已经发现外泌体可以被相邻或远处的细胞吸收，通过关注mRNA来控制基因表达的转录后调控。已发现外泌体miRNA具有一系列功能，包括参与炎症反应，细胞运动,增长,死亡,自噬,以及上皮-间质转化。越来越多的研究表明，外泌体miRNAs对心血管健康很重要，并且在许多心血管疾病的发展中起着重要作用。包括肺动脉高压,动脉粥样硬化,急性冠脉综合征,心力衰竭,和心肌缺血再灌注损伤。本文就miR-155及其外泌体形式在心脏疾病中的作用作一综述。
