PDF(Pubmed)
Abstract：
Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES.
摘要：
青春期的特点是动态的神经发育，这给风险和韧性带来了机会。不良的童年经历（ACE）会给发育中的大脑带来额外的风险，其中ACE与抑制控制基础脑区功能磁共振成像（fMRI）BOLD信号传导的改变有关。家庭环境等社会环境因素可能会放大或缓冲与ACE相关的神经发育风险。使用基线到2年随访数据从青少年脑认知发育（ABCD）研究，本研究调查了在与抑制控制相关的区域中,成功抑制停止信号任务过程中ACE与fMRIBOLD信号传导的关系,并研究了家庭冲突水平是否缓和了这种关系.结果表明，较高的ACE与右额下回手术区和补充前运动区两侧的BOLD反应降低有关，这是抑制控制的关键区域。Further,较大的BOLD反应与较少的行为冲动相关，提示在这个年龄段，减少的激活可能不是行为适应性的。没有发现与家庭冲突水平或时间的显着双向或三向互动。研究结果强调了检查ACE与神经发育结局之间关系的持续实用性以及干预/预防ACES的重要性。
