Abstract：
Previous research has shown a decrease in serum testosterone levels in male patients with depression. In recent years, the results of testosterone replacement therapy (TRT) to improve depression have been mixed. Using the classic CUMS model, we induced depressive-like behaviors in rats and observed a decrease in their serum testosterone levels along with an increase in androgen receptor expression in the hippocampus. We then performed castration and sham surgery on male rats and found that testosterone deprivation led to the manifestation of depressive-like behavior that could be ameliorated by TRT. Through a repeated measures experiment consisting of five blocks over a period of 25 days, we discovered that the reduction in depressive-like behavior in testosterone-deprived rats began 22 days after drug administration (0.5 and 0.25 mg/rat). Furthermore, rats in 0.5mgT group showed the most significant improvements. Subsequently, this dose was used in CUMS rats and reduced the occurrence of depressive-like behaviors. Our study has demonstrated the complex interplay between depression and testosterone, as well as the intricate dose-response relationship between TRT and reduction in depression. Our research supports the use of TRT to alleviate depression, but dosage and duration of treatment are critical factors in determining efficacy.
摘要：
先前的研究表明，男性抑郁症患者的血清睾酮水平降低。近年来,睾酮替代疗法(TRT)改善抑郁的结果喜忧参半.使用经典的CUMS模型，我们在大鼠中诱导了抑郁样行为，并观察到血清睾酮水平降低，海马中雄激素受体表达增加。然后，我们对雄性大鼠进行了去势和假手术，发现睾丸激素剥夺导致抑郁样行为的表现，可以通过TRT改善。通过在25天的时间内进行由五个街区组成的重复测量实验，我们发现,睾酮剥夺大鼠的抑郁样行为在给药后22天开始减少(0.5和0.25mg/只).此外，0.5mgT组大鼠的改善最为显著。随后，该剂量用于CUMS大鼠,可减少抑郁样行为的发生.我们的研究证明了抑郁症和睾酮之间复杂的相互作用，以及TRT与抑郁症减轻之间复杂的剂量-反应关系。我们的研究支持使用TRT来缓解抑郁症，但治疗剂量和持续时间是决定疗效的关键因素。
