Abstract：
Degenerative intervertebral disc disease (IVDD) is one of the main spinal surgery, conditions, which markedly increases the incidence of low back pain and deteriorates the patient\'s quality of life, and it imposes significant social and economic burdens. The molecular pathology of IVDD is highly complex and multilateral however still not ompletely understood. New findings indicate that IVDD is closely associated with inflammation, oxidative stress, cell injury and extracellular matrix metabolismdysregulation. Symptomatic management is the main therapeutic approach adopted for IVDD, but it fails to address the basic pathological changes and the causes of the disease. However, research is still focusing on molecular aspects in terms of gene expression, growth factors and cell signaling pathways in an attempt to identify specific molecular targets for IVDD treatment. The paper summarizes the most recent achievements in molecularunderstanding of the pathogenesis of IVDD and gives evidence-based recommendations for clinical practice.
摘要：
退变性椎间盘疾病(IVDD)是脊柱外科的主要疾病之一,条件,这显著增加了腰背痛的发生率，并恶化了患者的生活质量，它带来了巨大的社会和经济负担。IVDD的分子病理学是高度复杂和多边的，但仍未完全理解。新发现表明IVDD与炎症密切相关，氧化应激，细胞损伤和细胞外基质代谢失调。症状管理是IVDD采用的主要治疗方法，但它未能解决基本的病理变化和疾病的原因。然而,研究仍集中在基因表达方面的分子方面，试图确定IVDD治疗的特定分子靶标。本文总结了分子理解IVDD发病机制的最新成果，并为临床实践提供循证建议。
