PDF(Pubmed)
Abstract：
Acne is a multifactorial and common disorder among young people and a frequent reason for dermatology consultation. When moderate-to-severe acne is not responsive to conventional treatments, oral isotretinoin is a very effective solution. However, there are cases in which this treatment fails to produce the expected results. In this case, an 18-year-old male patient with acne, unresponsive to traditional acne therapies, experienced only a partial benefit from oral isotretinoin. Endocrinology consultation and hormonal work-up revealed androgen metabolism anomalies suggestive of a non-classical form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. In this case report, the authors discuss when to suspect, how to diagnose, and how to manage similar cases.
摘要：
痤疮是年轻人中的一种多因素和常见疾病，也是皮肤科咨询的常见原因。当中度至重度痤疮对常规治疗无反应时，口服异维A酸是一种非常有效的解决方案。然而,在某些情况下，这种治疗不能产生预期的结果。在这种情况下,一名18岁的男性痤疮患者,对传统的痤疮疗法没有反应，口服异维A酸仅部分受益。内分泌学咨询和激素检查显示，雄激素代谢异常提示由于21-羟化酶缺乏症导致的先天性肾上腺增生的非经典形式。在这个案例报告中,作者讨论何时怀疑，如何诊断,以及如何处理类似的案件。
