PDF(Pubmed)
Abstract：
Diffuse tenosynovial giant cell tumor (D-TGCT), previously known as pigmented villonodular synovitis (PVNS), is a benign, aggressive, and distracting proliferative synovial lesion. D-TGCT is commonly seen in large joints such as the knee and hip. We present the case of a 57-year-old female who initially presented with swelling on the left midfoot that increased over four years. Clinically, a ganglion was suspected on the left midfoot and an MRI showed a heterogeneous lobulated soft tissue mass on the superior aspect of the tarsal midfoot measuring 5.8 x 2.4 x 4.2 cm. The mass causing remodeling and bony erosion was more appreciated at the medial aspect of the talus bone and extended to the sinus tarsi and talocalcaneal joint space. Surgical excision of the mass was performed, and pathology reports found lobulated soft tissue lesions composed of mononuclear cells, multinucleated giant cells, sheets of foamy macrophages, inflammatory cells, and hemosiderin-laden macrophages. This case represents D-TGCT without atypia or malignancy based on the findings.
摘要：
弥漫性腱鞘膜巨细胞瘤(D-TGCT),以前称为色素沉着绒毛结节性滑膜炎（PVNS），是良性的，侵略性,和分散的增生性滑膜病变。D-TGCT常见于大关节，如膝关节和髋关节。我们介绍了一名57岁的女性，该女性最初表现为左中足肿胀，超过四年。临床上,怀疑左中足有神经节，MRI显示，在tan骨中足上部有一个不均匀的分叶状软组织肿块，大小为5.8x2.4x4.2cm。在距骨的内侧，引起重塑和骨侵蚀的肿块更受重视，并延伸到tar骨窦和距骨关节间隙。对肿块进行了手术切除，病理报告发现由单核细胞组成的分叶状软组织病变，多核巨细胞,成片的泡沫巨噬细胞，炎症细胞，和含铁血黄素的巨噬细胞.根据发现，该病例代表D-TGCT，无异型或恶性肿瘤。
