METHODS: We evaluated the following nebulizer-compressor combinations (n = 5 replicates): 1. OMBRA® Table Top Compressor with MC 300® reusable and Airlife™ MistyMax™ 10® disposable nebulizer, 2. Sami-the-Seal® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 3. VIOS® compressor with LC Sprint® reusable, and VixOne® and Airlife™ MistyMax™ disposable nebulizers, 4. Innospire® Elegance® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 5. Willis-the-Whale® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 6. Pari PRONEB® Max compressor with LC Sprint® reusable and Airlife™ MistyMax 10™ disposable nebulizer. We placed a 3-ml albuterol solution (0.833 mg/ml) in each nebulizer. A bacterial/viral filter was attached to the nebulizer mouthpiece to capture emitted medication, with the filter exit coupled to a simulator of a tidal breathing adult (rate = 10 cycles/min; Vt = 600 ml; I/E ratio = 1:2). The filter was replaced at 1-min intervals until onset of sputter. Droplet size distributions (n = 5 replicates/system) were determined in parallel by laser diffractometry.
RESULTS: Cumulative FDM<4.7 μm varied from 381 ± 33 μg for the best performing combination (Proneb/LC-Sprint) to 150 ± 21 μg for the system with the lowest output (VIOS®/MistyMax 10™).
CONCLUSIONS: Substituting one nebulizer for another can result in large differences in medication delivery to the lungs.
方法:我们评估了以下雾化器-压缩机组合(n=5个重复):1.OMBRA®台式压缩机,配有MC300®可重复使用和Airlife™MistyMax™10®一次性雾化器,2.Sami-the-Seal®压缩机,配有SideStream®可重复使用的一次性雾化器和Airlife™MistyMax10™一次性雾化器,3.带LCSprint®的VIOS®压缩机可重复使用,和VixOne®和Airlife™MistyMax™一次性雾化器,4.Innospire®Elegance®压缩机,配有SideStream®可重复使用的一次性雾化器和Airlife™MistyMax10™一次性雾化器,5.Willis-the-Whale®压缩机,配有SideStream®可重复使用的一次性雾化器和Airlife™MistyMax10™一次性雾化器,6.带有LCSprint®可重复使用和Airlife™MistyMax10™一次性雾化器的PariPRONEB®Max压缩机。我们在每个雾化器中放置3ml沙丁胺醇溶液(0.833mg/ml)。将细菌/病毒过滤器连接到雾化器口管以捕获发出的药物,过滤器出口耦合到潮式呼吸成人的模拟器(速率=10周期/分钟;Vt=600ml;I/E比=1:2)。以1分钟的间隔更换过滤器直到溅射开始。通过激光衍射法平行测定液滴尺寸分布(n=5次重复/系统)。
结果:累积FDM<4.7μm,从性能最佳的组合(Proneb/LC-Sprint)的381±33μg到输出最低的系统(VIOS®/MistyMax10™)的150±21μg不等。
结论:用一种雾化器代替另一种雾化器会导致肺部给药的差异很大。