PDF(Pubmed)
Abstract：
BACKGROUND: Toxoplasmosis is a worldwide parasitic zoonosis caused by the protozoan Toxoplasma gondii. In cases of vertical infection, and in immunosuppressed people by the human immunodeficiency virus (HIV) serious clinical conditions may appear, while immunocompetent people do not present symptoms. However, T. gondii infection has been linked to several mental disorders for decades.
OBJECTIVE: To substantiate the possible relationship between T. gondii and mental disorders and suggest control and prevention strategies.
METHODS: A systematic review has been carried out to analyze the relationship between T. gondii exposure (presence of IgG) and the onset of mental disorders in minors and adults. The etiopathogenic mechanisms described by the authors have also been included and the systems of surveillance, prevention and control of infection have been evaluated.
RESULTS: Several processes linked to the presence of cysts and the reactivation of the parasite in certain situations produce an immune and inflammatory response. Also, direct and indirect actions on different neurotransmitters. These mechanisms, together with other environmental and genetic factors, would predispose to different psychiatric pathologies.
CONCLUSIONS: Due to the limits of the study, no conclusions can be drawn in childhood and adolescence. However, the results of this systematic review show a possible association of schizophrenia, bipolar disorder and compulsive disorder with T. gondii infection in adults. There is a need to improve control, integrated surveillance and extend prevention measures to the entire population.
OBJECTIVE: To substantiate the possible relationship between T. gondii and mental disorders and suggest control and prevention strategies.
METHODS: A systematic review has been carried out to analyze the relationship between T. gondii exposure (presence of IgG) and the onset of mental disorders in minors and adults. The etiopathogenic mechanisms described by the authors have also been included and the systems of surveillance, prevention and control of infection have been evaluated.
RESULTS: Several processes linked to the presence of cysts and the reactivation of the parasite in certain situations produce an immune and inflammatory response. Also, direct and indirect actions on different neurotransmitters. These mechanisms, together with other environmental and genetic factors, would predispose to different psychiatric pathologies.
CONCLUSIONS: Due to the limits of the study, no conclusions can be drawn in childhood and adolescence. However, the results of this systematic review show a possible association of schizophrenia, bipolar disorder and compulsive disorder with T. gondii infection in adults. There is a need to improve control, integrated surveillance and extend prevention measures to the entire population.
摘要：
背景：弓形虫病是由原生动物弓形虫引起的世界性寄生虫人畜共患病。在垂直感染的情况下，而在免疫抑制人群中可能出现人类免疫缺陷病毒(HIV)严重的临床病症,而有免疫能力的人不出现症状。然而,几十年来，弓形虫感染与几种精神障碍有关。
目的：证实弓形虫与精神障碍之间的可能关系，并提出控制和预防策略。
方法：已经进行了系统评价，以分析弓形虫暴露（IgG的存在）与未成年人和成年人精神障碍发作之间的关系。作者描述的致病机制也包括和监测系统，已经评估了感染的预防和控制。
结果：在某些情况下，与囊肿的存在和寄生虫的再激活有关的几个过程会产生免疫和炎症反应。此外，对不同神经递质的直接和间接作用。这些机制,连同其他环境和遗传因素，会容易患上不同的精神病.
结论：由于研究的局限性，在童年和青春期没有结论。然而,这项系统评价的结果显示了精神分裂症的可能关联，成人双相情感障碍和强迫症伴弓形虫感染。有必要改善控制，综合监测并将预防措施扩展到整个人口。
目的：证实弓形虫与精神障碍之间的可能关系，并提出控制和预防策略。
方法：已经进行了系统评价，以分析弓形虫暴露（IgG的存在）与未成年人和成年人精神障碍发作之间的关系。作者描述的致病机制也包括和监测系统，已经评估了感染的预防和控制。
结果：在某些情况下，与囊肿的存在和寄生虫的再激活有关的几个过程会产生免疫和炎症反应。此外，对不同神经递质的直接和间接作用。这些机制,连同其他环境和遗传因素，会容易患上不同的精神病.
结论：由于研究的局限性，在童年和青春期没有结论。然而,这项系统评价的结果显示了精神分裂症的可能关联，成人双相情感障碍和强迫症伴弓形虫感染。有必要改善控制，综合监测并将预防措施扩展到整个人口。
