PDF(Pubmed)
Abstract：
Associative learning can drive many different types of behaviors, including food consumption. Previous studies have shown that cues paired with food delivery while mice are hungry will lead to increased consumption in the presence of those cues at later times. We previously showed that overconsumption can be driven in male mice by contextual cues, using chow pellets. Here we extended our findings by examining other parameters that may influence the outcome of context-conditioned overconsumption training. We found that the task worked equally well in males and females, and that palatable substances such as high-fat diet and Ensure chocolate milkshake supported learning and induced overconsumption. Surprisingly, mice did not overconsume when sucrose was used as the reinforcer during training, suggesting that nutritional content is a critical factor. Interestingly, we also observed that diet-induced obese mice did not learn the task. Overall, we find that context-conditioned overconsumption can be studied in lean male and female mice, and with multiple reinforcer types.
摘要：
联想学习可以驱动许多不同类型的行为，包括食物消费。先前的研究表明，当小鼠饥饿时，与食物递送配对的线索会导致在以后出现这些线索的情况下消耗增加。我们之前表明，在雄性小鼠中，过度消费可以由背景线索驱动，使用食物颗粒。在这里，我们通过检查可能影响上下文条件下的过度消费培训结果的其他参数来扩展我们的发现。我们发现这项任务在男性和女性中同样有效，以及可口的物质，如高脂肪饮食和确保巧克力奶昔支持学习和诱导过度消费。令人惊讶的是,当在训练期间使用蔗糖作为增强剂时，小鼠没有过度消耗，这表明营养成分是一个关键因素。有趣的是,我们还观察到饮食诱导的肥胖小鼠没有学习这项任务.总的来说,我们发现上下文条件的过度消费可以在瘦弱的雄性和雌性小鼠中进行研究，并具有多个加强件类型。
