PDF(Pubmed)
Abstract：
UNASSIGNED: We analysed the neurological complications of patients with severe SARS-CoV-2 infection who required intensive care unit (ICU) admission.
UNASSIGNED: We conducted a retrospective, observational, descriptive study of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020.
UNASSIGNED: We included 30 patients with neurological symptoms; 21 were men (72.40%), and mean age (standard deviation [SD]) was 57.41 years (11.61). The mean duration of ICU stay was 18.83 days (14.33). The neurological conditions recorded were acute confusional syndrome in 28 patients (93.33%), neuromuscular disease in 15 (50%), headache in 5 (16.66%), cerebrovascular disease in 4 (13.33%), and encephalopathies/encephalitis in 4 (13.33%). CSF analysis results were normal in 6 patients (20%). Brain MRI or head CT showed alterations in 20 patients (66.6%). EEG was performed in all patients (100%), with 8 (26.66%) showing abnormal findings. In 5 of the 15 patients with clinical myopathy, diagnosis was confirmed with electroneuromyography. We found a correlation between older age and duration of ICU stay (P = .002; 95% CI: 4.032-6.022; OR: 3,594).
UNASSIGNED: Severe COVID-19 mainly affects men, as observed in other series. Half of our patients presented acute myopathy, and almost all patients left the ICU with acute confusional syndrome, which fully resolved; no correlation was found with EEG or neuroimaging findings. Older age is associated with longer ICU stay.
UNASSIGNED: We conducted a retrospective, observational, descriptive study of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020.
UNASSIGNED: We included 30 patients with neurological symptoms; 21 were men (72.40%), and mean age (standard deviation [SD]) was 57.41 years (11.61). The mean duration of ICU stay was 18.83 days (14.33). The neurological conditions recorded were acute confusional syndrome in 28 patients (93.33%), neuromuscular disease in 15 (50%), headache in 5 (16.66%), cerebrovascular disease in 4 (13.33%), and encephalopathies/encephalitis in 4 (13.33%). CSF analysis results were normal in 6 patients (20%). Brain MRI or head CT showed alterations in 20 patients (66.6%). EEG was performed in all patients (100%), with 8 (26.66%) showing abnormal findings. In 5 of the 15 patients with clinical myopathy, diagnosis was confirmed with electroneuromyography. We found a correlation between older age and duration of ICU stay (P = .002; 95% CI: 4.032-6.022; OR: 3,594).
UNASSIGNED: Severe COVID-19 mainly affects men, as observed in other series. Half of our patients presented acute myopathy, and almost all patients left the ICU with acute confusional syndrome, which fully resolved; no correlation was found with EEG or neuroimaging findings. Older age is associated with longer ICU stay.
摘要：
■我们分析了需要入住重症监护病房（ICU）的严重SARS-CoV-2感染患者的神经系统并发症。
■我们进行了回顾，观察,对2020年4月1日至6月1日期间因SARS-CoV-2感染继发严重呼吸道症状而连续入住ICU的患者进行描述性研究.
■我们纳入了30例有神经系统症状的患者；21例为男性（72.40%），平均年龄（标准差[SD]）为57.41岁（11.61）。ICU住院时间平均为18.83天（14.33）。记录的神经系统状况为28例（93.33％）的急性混乱综合征，神经肌肉疾病15（50％），头痛5例（16.66%），4例脑血管病（13.33%），和脑病/脑炎4（13.33%）。脑脊液分析结果正常6例(20%)。脑部MRI或头部CT显示20例患者（66.6％）的改变。所有患者（100%）进行脑电图检查，8（26.66%）显示异常发现。在15例临床肌病患者中，有5例，诊断通过神经肌电图证实。我们发现年龄与ICU住院时间之间存在相关性（P=.002；95％CI：4.032-6.022；OR：3,594）。
■严重的COVID-19主要影响男性，在其他系列中观察到的。我们一半的病人出现急性肌病,几乎所有的病人都因急性混乱综合征离开ICU,完全解决；未发现与EEG或神经影像学检查结果相关。年龄较大与ICU停留时间较长有关。
■我们进行了回顾，观察,对2020年4月1日至6月1日期间因SARS-CoV-2感染继发严重呼吸道症状而连续入住ICU的患者进行描述性研究.
■我们纳入了30例有神经系统症状的患者；21例为男性（72.40%），平均年龄（标准差[SD]）为57.41岁（11.61）。ICU住院时间平均为18.83天（14.33）。记录的神经系统状况为28例（93.33％）的急性混乱综合征，神经肌肉疾病15（50％），头痛5例（16.66%），4例脑血管病（13.33%），和脑病/脑炎4（13.33%）。脑脊液分析结果正常6例(20%)。脑部MRI或头部CT显示20例患者（66.6％）的改变。所有患者（100%）进行脑电图检查，8（26.66%）显示异常发现。在15例临床肌病患者中，有5例，诊断通过神经肌电图证实。我们发现年龄与ICU住院时间之间存在相关性（P=.002；95％CI：4.032-6.022；OR：3,594）。
■严重的COVID-19主要影响男性，在其他系列中观察到的。我们一半的病人出现急性肌病,几乎所有的病人都因急性混乱综合征离开ICU,完全解决；未发现与EEG或神经影像学检查结果相关。年龄较大与ICU停留时间较长有关。
