Abstract：
The purpose of this in vitro study was to evaluate the impact of the vertical level of the stopcock connecting the infusion line to the central venous catheter on start-up fluid delivery in microinfusions. Start-up fluid delivery was measured under standardized conditions with the syringe outlet and liquid flow sensors positioned at heart level (0 cm) and exposed to a simulated CVP of 10 mmHg at a set flow rate of 1 ml/h. Flow and intraluminal pressures were measured with the infusion line connected to the stopcock primarily placed at vertical levels of 0 cm, + 30 cm and - 30 cm or primarily placed at 0 cm and secondarily, after connecting the infusion line, displaced to + 30 cm and - 30 cm. Start-up fluid delivery 10 s after opening the stopcock placed at zero level and after opening the stopcock primarily connected at zero level and secondary displaced to vertical levels of + 30 cm and - 30 cm were similar (- 10.52 [- 13.85 to - 7.19] µL; - 8.84 [- 12.34 to - 5.33] µL and - 11.19 [- 13.71 to - 8.67] µL (p = 0.469)). Fluid delivered at 360 s related to 65% (zero level), 71% (+ 30 cm) and 67% (- 30 cm) of calculated infusion volume (p = 0.395). Start-up fluid delivery with the stopcock primarily placed at + 30 cm and - 30 cm resulted in large anterograde and retrograde fluid volumes of 34.39 [33.43 to 35.34] µL and - 24.90 [- 27.79 to - 22.01] µL at 10 s, respectively (p < 0.0001). Fluid delivered with the stopcock primarily placed at + 30 cm and - 30 cm resulted in 140% and 35% of calculated volume at 360 s, respectively (p < 0.0001). Syringe infusion pumps should ideally be connected to the stopcock positioned at heart level in order to minimize the amounts of anterograde and retrograde fluid volumes after opening of the stopcock.
摘要：
这项体外研究的目的是评估将输注管线连接到中心静脉导管的旋塞的垂直水平对微量输注中的启动流体输送的影响。在标准化条件下测量启动流体输送,其中注射器出口和液体流量传感器定位在心脏水平(0cm)处并以1ml/h的设定流速暴露于10mmHg的模拟CVP。流量和腔内压力是用输液管连接到主要放置在垂直水平0厘米的旋塞测量的。+30厘米和-30厘米或主要放置在0厘米，其次，在连接输液管之后,位移到+30厘米和-30厘米。打开置于零位的旋塞阀10s后和打开主要连接在零位的旋塞阀10s后,二次位移至+30cm和-30cm的垂直水平的启动流体输送相似(-10.52[-13.85至-7.19]微升;-8.84[-12.34至-5.33]微升和-11.19[-13.71至-8.67]微升(p=0.469))。以360秒输送的流体与65%相关(零水平)，计算输注量的71%(+30cm)和67%(-30cm)(p=0.395)。将旋塞主要放置在+30cm和-30cm处的启动流体输送导致在10s时出现34.39[33.43至35.34]微升和-24.90[-27.79至-22.01]微升的大的顺行和逆行流体体积,分别(p<0.0001)。主要放置在+30cm和-30cm处的旋塞输送的流体在360s时产生140%和35%的计算体积,分别(p<0.0001)。注射器输液泵应理想地连接到位于心脏水平的旋塞,以便在旋塞打开后最小化顺行和逆行流体体积的量。
