Abstract：
OBJECTIVE: The purpose of this study was to use the MR method to explore the causal relationship between 211 gut microbiota and male reproductive and sexual health.
METHODS: The MiBioGen alliance published genome-wide association study (GWAS) related genetic variation data was used as instrumental variables (IVs) for gut microbiota, and the Finngen biobank GWAS related genetic variation data was used as IVs for male infertility, abnormal sperm, sexual dysfunction, erectile dysfunction, and testicular dysfunction. The inverse variance-weighted (IVW) method was used as the MR analysis method, the results were evaluated according to the odds ratio and 95% confidence interval of the effect measures, and data sensitivity analysis was performed.
RESULTS: The results showed that 6 types of gut microbiota were related to male infertility, 12 types were related to abnormal sperm, 5 types were related to sexual dysfunction, 4 types were related to erectile dysfunction, and 4 types were related to testicular dysfunction. And there was no abnormality in the data sensitivity analysis.
CONCLUSIONS: The intestinal microbiota is closely related to male reproductive and sexual health.
METHODS: The MiBioGen alliance published genome-wide association study (GWAS) related genetic variation data was used as instrumental variables (IVs) for gut microbiota, and the Finngen biobank GWAS related genetic variation data was used as IVs for male infertility, abnormal sperm, sexual dysfunction, erectile dysfunction, and testicular dysfunction. The inverse variance-weighted (IVW) method was used as the MR analysis method, the results were evaluated according to the odds ratio and 95% confidence interval of the effect measures, and data sensitivity analysis was performed.
RESULTS: The results showed that 6 types of gut microbiota were related to male infertility, 12 types were related to abnormal sperm, 5 types were related to sexual dysfunction, 4 types were related to erectile dysfunction, and 4 types were related to testicular dysfunction. And there was no abnormality in the data sensitivity analysis.
CONCLUSIONS: The intestinal microbiota is closely related to male reproductive and sexual health.
摘要：
目的：本研究的目的是使用MR方法探讨211肠道菌群与男性生殖和性健康之间的因果关系。
方法：MiBioGen联盟发布的全基因组关联研究（GWAS）相关的遗传变异数据被用作肠道微生物群的工具变量（IV），Finngen生物样本库GWAS相关的遗传变异数据被用作男性不育的IVs，精子异常,性功能障碍,勃起功能障碍,和睾丸功能障碍.采用逆方差加权(IVW)方法作为MR分析方法，根据效果测量的比值比和95%置信区间对结果进行评估，并进行数据敏感性分析。
结果：结果显示，6种类型的肠道菌群与男性不育有关，12种类型与异常精子有关，5种类型与性功能障碍有关，4种类型与勃起功能障碍有关，4种类型与睾丸功能障碍有关。数据敏感性分析无异常。
结论：肠道菌群与男性生殖健康和性健康密切相关。
方法：MiBioGen联盟发布的全基因组关联研究（GWAS）相关的遗传变异数据被用作肠道微生物群的工具变量（IV），Finngen生物样本库GWAS相关的遗传变异数据被用作男性不育的IVs，精子异常,性功能障碍,勃起功能障碍,和睾丸功能障碍.采用逆方差加权(IVW)方法作为MR分析方法，根据效果测量的比值比和95%置信区间对结果进行评估，并进行数据敏感性分析。
结果：结果显示，6种类型的肠道菌群与男性不育有关，12种类型与异常精子有关，5种类型与性功能障碍有关，4种类型与勃起功能障碍有关，4种类型与睾丸功能障碍有关。数据敏感性分析无异常。
结论：肠道菌群与男性生殖健康和性健康密切相关。
