PDF(Pubmed)
Abstract：
Pulmonary mucormycosis is a severe and often fatal disease that commonly affects patients with underlying conditions, such as diabetes. Early diagnosis and appropriate treatment are crucial for improving survival rates. However, clinical diagnosis remains challenging due to difficulty in obtaining etiological evidence. In this particular case, the patient presented with a cough-producing bloody sputum, and a chest CT revealed lesions in the right upper lobe of the lung. The patient was ultimately diagnosed with pulmonary mucormycosis caused by Rhizopus delemar through clinical bronchoscopy biopsy and metagenomic next-generation sequencing (mNGS) analysis of bronchoalveolar lavage fluid sample. Subsequently, antifungal therapy using the less toxic Amphotericin B cholesterol Organosulfate complex was initiated, improving the patient\'s condition. In conclusion, our findings underscore the potential of mNGS to provide an accurate and rapid etiological diagnosis of pulmonary mucormycosis, offering a foundation for treatment.
摘要：
肺毛霉菌病是一种严重且通常致命的疾病，通常会影响患有潜在疾病的患者。比如糖尿病。早期诊断和适当的治疗对于提高生存率至关重要。然而,由于获取病因学证据困难,临床诊断仍然具有挑战性.在这种特殊情况下，病人出现了咳嗽引起的血痰，胸部CT显示右肺上叶有病变.通过临床支气管镜活检和支气管肺泡灌洗液样本的宏基因组下一代测序（mNGS）分析，该患者最终被诊断为由根霉引起的肺毛霉菌病。随后，开始使用毒性较小的两性霉素B胆固醇有机硫酸盐复合物进行抗真菌治疗，改善病人的病情。总之,我们的研究结果强调了mNGS提供肺毛霉菌病的准确和快速病因诊断的潜力，为治疗提供基础。
