PDF(Pubmed)
Abstract：
Non-healing wounds profoundly impact patient quality of life and present a significant financial burden. The Kerecis™ fish skin xenograft is a decellularized skin matrix that has been introduced to treat complicated wounds. The objective of this presentation is to highlight the use of fish skin xenograft in the treatment of a complex right flank wound with stool contamination, necrotizing soft tissue infection due to perforated colon cancer, and sepsis. This presentation follows the wound healing for 28 days following the operation and demonstrates the efficacy of fish skin xenografts in improved wound healing. A 61-year-old female with a past medical history of colon cancer and recent chemotherapy treatment presented with colon perforation causing right flank cellulitis and sepsis with necrotic abdominal wall tissue extending into the hip joint. She was taken for an emergent exploratory laparotomy, drainage of abdominal and retroperitoneal abscesses, open right hemicolectomy, diverting ileostomy, abdominal washout, intra-abdominal omental patch, placement of Strattice mesh, and debridement of necrotizing soft tissue infection of the right flank. After extensive debridement of her 15x10cmx5cm deep wound and placement of a Kerecis™ fish skin xenograft, the wound had completely healed with excellent granulation tissue, and the patient was scheduled for placement of a skin graft 28 days following the initial procedure. The results after xenograft application were outstanding, supporting the use of polyunsaturated fatty acid (PUFA) based xenografts in wound treatment due to their anti-inflammatory and angiogenic properties. This is definitely an option that needs to be considered in expediting the healing process for complex wounds.
摘要：
不愈合的伤口深刻地影响患者的生活质量并带来显著的经济负担。Kerecis™鱼皮异种移植物是一种脱细胞皮肤基质，已被引入治疗复杂的伤口。本报告的目的是强调使用鱼皮异种移植物治疗复杂的右侧伤口有粪便污染，结肠癌穿孔引起的坏死性软组织感染，还有败血症.该演示遵循手术后28天的伤口愈合，并证明了鱼皮异种移植物在改善伤口愈合中的功效。一名61岁的女性，既往有结肠癌病史，最近接受过化疗，表现为结肠穿孔，导致右侧腹蜂窝织炎和败血症，坏死性腹壁组织延伸至髋关节。她被带去做紧急剖腹探查术,腹腔和腹膜后脓肿引流，开腹右半结肠切除术,分流回肠造口术，腹部冲洗，腹内网膜补片，格栅网的放置,和右侧部坏死性软组织感染的清创术。在对她的15x10cmx5cm深的伤口进行广泛清创术并放置了Keeris™鱼皮异种移植物后，伤口完全愈合，肉芽组织良好，患者计划在初次手术后28天放置皮肤移植物。异种移植后的结果非常出色，由于其抗炎和血管生成特性,支持基于多不饱和脂肪酸(PUFA)的异种移植物在伤口治疗中的使用。这绝对是在加快复杂伤口的愈合过程中需要考虑的选项。
