PDF(Pubmed)
Abstract：
At present, diabetes mellitus (DM) has been one of the most endangering healthy diseases. Current therapies contain controlling high blood sugar, reducing risk factors like obesity, hypertension, and so on; however, DM patients inevitably and eventually progress into different types of diabetes complications, resulting in poor quality of life. Unfortunately, the clear etiology and pathogenesis of diabetes complications have not been elucidated owing to intricate whole-body systems. The immune system was responsible to regulate homeostasis by triggering or resolving inflammatory response, indicating it may be necessary to diabetes complications. In fact, previous studies have been shown inflammation plays multifunctional roles in the pathogenesis of diabetes complications and is attracting attention to be the meaningful therapeutic strategy. To this end, this review systematically concluded the current studies over the relationships of susceptible diabetes complications (e.g., diabetic cardiomyopathy, diabetic retinopathy, diabetic peripheral neuropathy, and diabetic nephropathy) and inflammation, ranging from immune cell response, cytokines interaction to pathomechanism of organ injury. Besides, we also summarized various therapeutic strategies to improve diabetes complications by target inflammation from special remedies to conventional lifestyle changes. This review will offer a panoramic insight into the mechanisms of diabetes complications from an inflammatory perspective and also discuss contemporary clinical interventions.
摘要：
目前,糖尿病(DM)是危害健康的疾病之一。目前的疗法包括控制高血糖，减少肥胖等风险因素，高血压,等等；然而，DM患者不可避免地并最终发展成不同类型的糖尿病并发症,导致生活质量差。不幸的是,由于复杂的全身系统，糖尿病并发症的病因和发病机制尚未阐明。免疫系统负责通过触发或解决炎症反应来调节体内平衡，提示糖尿病并发症可能是必要的。事实上,既往研究表明,炎症在糖尿病并发症的发病机制中起着多功能作用,并成为有意义的治疗策略。为此,这篇综述系统地总结了目前关于易感糖尿病并发症关系的研究(例如，糖尿病性心肌病,糖尿病视网膜病变，糖尿病周围神经病变，和糖尿病肾病）和炎症，从免疫细胞反应，细胞因子与器官损伤病理机制的相互作用。此外,我们还总结了通过从特殊治疗到常规生活方式改变的靶向炎症改善糖尿病并发症的各种治疗策略.这篇综述将从炎症角度提供对糖尿病并发症机制的全景见解，并讨论当代临床干预措施。
