UNASSIGNED: Hospitalized patients diagnosed as positive for anti-neurofascin-155 (NF155)-positive autoimmune nodopathy (AN) (NF155+), chronic inflammatory demyelinating polyneuropathy (CIDP), or multifocal motor neuropathy (MMN) at Huashan Hospital of Fudan University in Shanghai, China, who underwent brachial plexus MRI between October 2011 and August 2023 were consecutively recruited for this study. We also recruited participants who underwent brachial plexus MRI during this period with no history of trauma, inflammation, tumors, compression, or degenerative conditions as healthy controls. According to our self-developed semiquantitative assessment of preganglionic nerves, we assessed the bilateral preganglionic C5-C8 nerves individually and scored the enlargement degree from 0 to 4 points. Furthermore, a sum score ≥20 was defined as definite enlargement.
UNASSIGNED: A total of 122 participants were enrolled, including 28 with NF155+, 40 with CIDP, 15 with MMN, and 39 healthy controls. In the comparison of the single-nerve scores, we found that there was a significant difference distribution among the four groups (χ2 test; P<0.001), with the patients with NF155+ exhibiting the highest scores in each of the bilateral C5-C8 nerves. In the comparison of the sum scores, a descending tendency was observed in patients NF155+, CIDP, and MMN, with median scores of 11, 4, and 0 points, respectively (Kruskal-Wallis test; P=0.003, P<0.001, and P=0.005, respectively for NF155+ vs. CIDP, NF155+ vs. MMN, and CIDP vs. MMN). The proportion of definite enlargement in those with NF155+ was greater than that in healthy controls (21% vs. 0%; χ2 test; P=0.004), and the sum score at 0 points was lower in the NF155+ group than in CIDP, MMN, and healthy control groups (7% vs. 37%, 87%, and 41%, respectively; χ2 test; P<0.001).
UNASSIGNED: This semiquantitative assessment can be a valuable tool for measuring preganglionic nerve enlargement, which was found to be decreased, respectively, in those with NF155+, CIDP, and MMN. Presence of definite enlargement could be a strong indicator of NF155+ in clinic.
■住院患者被诊断为抗神经成束蛋白-155(NF155)阳性的自身免疫性神经病变(AN)(NF155)阳性,慢性炎性脱髓鞘性多发性神经病(CIDP),上海复旦大学附属华山医院多灶性运动神经病(MMN),中国,本研究连续招募在2011年10月至2023年8月期间接受臂丛MRI检查的患者.我们还招募了在此期间接受臂丛神经MRI检查的参与者,没有外伤史,炎症,肿瘤,压缩,或退行性疾病作为健康对照。根据我们对节前神经的半定量评估,我们分别评估了双侧节前C5-C8神经,并从0到4分进行扩大程度评分。此外,总分≥20被定义为明确的扩大。
■共有122名参与者注册,包括28个NF155+,40与CIDP,15与MMN,和39个健康对照。在单神经评分的比较中,我们发现四组之间存在显着差异分布(χ2检验;P<0.001),NF155+患者双侧C5-C8神经得分最高。在总分的比较中,在NF155+患者中观察到下降趋势,CIDP,还有MMN,中位数分别为11分、4分和0分,分别(Kruskal-Wallis检验;NF155与NF155分别为P=0.003,P<0.001和P=0.005CIDP,NF155+vs.MMN,andCIDPvs.MMN)。NF155+患者的明确扩大比例高于健康对照组(21%vs.0%;χ2检验;P=0.004),NF155+组的总分0分低于CIDP,MMN,和健康对照组(7%vs.37%,87%,41%,分别;χ2检验;P<0.001)。
■这种半定量评估可能是测量节前神经扩大的有价值的工具,被发现减少了,分别,在NF155+中,CIDP,和MMN。明确扩大的存在可能是NF155在临床上的有力指标。