关键词: ankylosing spondylitis cutaneous vasculitis leukocytoclastic vasculitis small vessel vasculitis

来  源:   DOI:10.1002/ccr3.8769   PDF(Pubmed)

Abstract:
UNASSIGNED: Although the concurrent occurrence of vasculitis with AS is uncommon, when patients diagnosed with AS exhibit symptoms including skin petechiae, purpura, abdominal discomfort, malaise, elevated ESR, and reduced complement levels, vigilant monitoring for vasculitis is advisable following the exclusion of secondary vasculitis triggers such as malignancies, infections, and pharmaceutical agents.
UNASSIGNED: The primary characteristic of ankylosing spondylitis (AS) involves inflammation occurring within the sacroiliac joint and the spine, leading to destruction and eventual ankylosis. A notably infrequent complication associated with AS is vasculitis, with limited reports linking AS to vasculitis. This case study documents a 48-year-old male, diagnosed with HLA-B27-positive AS for the past 15 years, who developed abdominal pain and skin lesions following the cessation of his medication on his own. Subsequent clinical evaluations identified leukocytoclastic vasculitis (LCV) related to AS after excluding all other potential causes of LCV, including drug-related sources, cancer, hepatitis B and C viruses, Henoch-Schönlein purpura (HSP), and IgA nephropathy.
摘要:
尽管并发血管炎并不常见,当被诊断为AS的患者表现出包括皮肤瘀斑的症状时,紫癜,腹部不适,萎靡不振,ESR升高,减少补体水平,在排除恶性肿瘤等继发性血管炎诱因后,建议对血管炎进行警惕监测,感染,和药剂。
强直性脊柱炎(AS)的主要特征涉及发生在骶髂关节和脊柱内的炎症,导致破坏和最终的强直。与AS相关的罕见并发症是血管炎,有限的报告将AS与血管炎联系起来。这个案例研究记录了一名48岁的男性,在过去的15年中被诊断为HLA-B27阳性AS,他停止服药后出现腹痛和皮肤损伤。随后的临床评估确定了与AS相关的白细胞碎裂性血管炎(LCV),排除了LCV的所有其他潜在原因。包括与毒品有关的来源,癌症,乙型肝炎和丙型肝炎病毒,过敏性紫癜(HSP),IgA肾病。
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